Entry Detail

General Information

Database ID: LDA0006178
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:WEE2-AS1
Full Name:WEE2 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):141704338End Site(bp):141738230
External Links:
Ensembl ID:ENSG00000261994
Ensembl Transcript ID:N/A
Entrez Gene:285962.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Arteriosclerosis Obliterans  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Glioma  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Arteriosclerosis Obliterans  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Glioma  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5160D001162
Disease Name:arteriosclerosis obliteransArteriosclerosis Obliterans
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.
Alias:Arteriosclerosis Obliterans//Obliterans, Arteriosclerosis

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
WEE2-AS1  (Score: 0.731059)
hsa_circ_0024093  (Score: 0.731059)
WEE2-AS1  (Score: 0.731059)
hsa_circ_0024093  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Flow Cytometry//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:33174040
Disease Name:Arteriosclerosis Obliterans
Sample:artery tissue,blood
Dysfunction Pattern:Expression[highly expressed]
Validated Method:CCK8//qRT-PCR//Flow Cytometry//Western Blot
Description:The results indicated that lncRNA WEE2?AS1 was significantly elevated in plasma and artery tissue samples of patients with ASO compared with healthy controls.
Causality:Yes
Causal Description: The Cell Counting Kit?8 assay results suggested that lncRNA WEE2?AS1 knockdown significantly promoted HUVEC viability, whereas lncRNA WEE2?AS1 overexpression inhibited HUVEC viability compared with the negative control groups.
Clinical-realted Application: