Entry Detail

General Information

Database ID: LDA0006192
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ZNF503-AS1
Full Name:ZNF503 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:10
Strand:+
Coordinate:
Start Site(bp):75296383End Site(bp):75361678
External Links:
Ensembl ID:ENSG00000226051
Ensembl Transcript ID:N/A
Entrez Gene:253264.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Urinary Bladder Neoplasms  (Score: 0.731059)
Diabetic Retinopathy  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Diabetic Retinopathy  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8947D003930
Disease Name:diabetic retinopathyDiabetic Retinopathy
Category:Disease OntologyMeSH
Type:Eye Diseases
Define:Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Alias:Retinal abnormality - diabetes-relatedDiabetic Retinopathy//Diabetic Retinopathies//Retinopathies, Diabetic//Retinopathy, Diabetic

 

Disease Association Statistics

Total Associated ncRNA Number:34   
More Information
Causal ncRNA Number:28
Network:
Top Causal ncRNAs:
ZNF503-AS1  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
FLG-AS1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
LINC00673  (Score: 0.731059)
SNHG16  (Score: 0.731059)
VEAL2  (Score: 0.731059)
MAP4K2  (Score: 0.731059)
TDRG1  (Score: 0.731059)
SNHG7  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35734878
Disease Name:Diabetic Retinopathy
Sample:patients with diabetic retinopathy
Dysfunction Pattern:Regulation( TGF-β signaling)
Validated Method:Western Blot//Transfection//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay
Description:We found that ZNF503-AS1 was not differentially expressed in healthy participants and diabetic patients. Plasma lncRNA ZNF503-AS1 level was higher in patients with diabetic retinopathy than in patients with other complications (p < 0.05). We concluded that ZNF503-AS1 might participate in diabetic retinopathy by activating TGF-β signaling.
Causality:Yes
Causal Description: ZNF503-AS1 overexpression inhibited proliferation, promoted cell apoptosis, and upregulated TGF-β1 expression (p < 0.05).
Clinical-realted Application:High plasma lncRNA ZNF503-AS1 level was correlated with a high incidence of diabetic retinopathy.