Entry Detail

General Information

Database ID: LDA0006234
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ZNF281
Full Name:zinc finger protein 281
Category:LncRNA
Species:Homo sapiens
Synonyms:GZP1|ZBP-99|ZBP99|ZNP-99
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):200404951End Site(bp):200410036
External Links:
Ensembl ID:ENSG00000162702
Ensembl Transcript ID:N/A
Entrez Gene:23528.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:12   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:1090   
More Information
Causal ncRNA Number:936
Network:
Top Causal ncRNAs:
AFAP1-AS1  (Score: 1)
FEZF1-AS1  (Score: 1)
BCYRN1  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
AWPPH  (Score: 1)
DANCR  (Score: 1)
hsa_circ_0007385  (Score: 1)
hsa_circ_0074027  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Flow Cytometry
Weak Evidence:

 

Reference

[1] PubMed ID:32782613
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:cancer tissues
Dysfunction Pattern:regulation[downregulation of microRNA-221]
Validated Method:CCK8//qRT-PCR//Flow Cytometry
Description: In patients with NSCLC, expression levels of ZNF281 were significantly lower in cancer tissues compared with in non-cancerous tissues, and lower levels of ZNF281 expression in cancerous tissues predicted poor survival.Therefore, ZNF281 may upregulate PTEN via downregulation of miR-221 in NSCLC, resulting in inhibition of cancer cell proliferation and the promotion of apoptosis.
Causality:Yes
Causal Description: In addition, ZNF281 and PTEN overexpression resulted in accelerated cell apoptosis and inhibited the cell proliferation of NSCLC cells.
Clinical-realted Application: In patients with NSCLC, expression levels of ZNF281 were significantly lower in cancer tissues compared with in non-cancerous tissues, and lower levels of ZNF281 expression in cancerous tissues predicted poor survival.