Entry Detail

General Information

Database ID: LDA0006238
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ZNF281
Full Name:zinc finger protein 281
Category:LncRNA
Species:Homo sapiens
Synonyms:GZP1|ZBP-99|ZBP99|ZNP-99
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):200404951End Site(bp):200410036
External Links:
Ensembl ID:ENSG00000162702
Ensembl Transcript ID:N/A
Entrez Gene:23528.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:12   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix//tumor of the Cervix Uteri//uterine cervical neoplasmUterine Cervical Neoplasms//Cervical Neoplasm, Uterine//Neoplasm, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasms, Cervix//Cervix Neoplasm//Neoplasm, Cervix//Cervix Neoplasms//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Cancer, Cervical//Cervical Cancers//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cervical Cancer, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix

 

Disease Association Statistics

Total Associated ncRNA Number:15334   
More Information
Causal ncRNA Number:532
Network:
Top Causal ncRNAs:
UCA1  (Score: 1)
CRNDE  (Score: 1)
WT1-AS  (Score: 1)
PVT1  (Score: 1)
LINC00511  (Score: 1)
DARS1-AS1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
OIP5-AS1  (Score: 1)
CRNDE  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34604953
Disease Name:Uterine Cervical Neoplasms
Sample:cervical carcinoma tissues and cell lines
Dysfunction Pattern:Regulation(KLF15 )
Validated Method:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Migration Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description: ZNF281 was upregulated in cervical carcinoma tissues and cell lines. KLF15 was the downstream gene binding ZNF281, and they were negatively correlated to each other in cervical carcinoma tissues. Notably, KLF15 was responsible for ZNF281-induced regulation on cervical carcinoma migration.
Causality:Yes
Causal Description:The knockdown of ZNF281 effectively attenuated migratory ability in HeLa and SiHa cells. Besides, knockdown of ZNF281 also reduced tumorigenicity of cervical carcinoma in nude mice.
Clinical-realted Application: It was correlated to TNM staging, and incidences of lymphatic metastasis and distant metastasis in cervical carcinoma patients, while it was unrelated to age and tumor size.