Entry Detail

General Information

Database ID: LDA0006259
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:XIST
Full Name:X inactive specific transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:DXS1089|DXS399E|LINC00001|NCRNA00001|SXI1|swd66
Chromosome:X
Strand:-
Coordinate:
Start Site(bp):73820651End Site(bp):73852753
External Links:
Ensembl ID:ENSG00000229807
Ensembl Transcript ID:N/A
Entrez Gene:7503.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:84
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Stomach Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Retinoblastoma  (Score: 1)
Retinoblastoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3829D010911
Disease Name:pituitary adenomaPituitary Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pituitary gland benign neoplasm that derives_from glandular epithelial cells.Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Alias:adenoma of the Pituitary glandPituitary Neoplasms//Neoplasm, Pituitary//Neoplasms, Pituitary//Pituitary Neoplasm//Pituitary Tumors//Pituitary Tumor//Tumor, Pituitary//Tumors, Pituitary//Pituitary Adenoma//Adenoma, Pituitary//Adenomas, Pituitary//Pituitary Adenomas//Pituitary Carcinoma//Carcinoma, Pituitary//Carcinomas, Pituitary//Pituitary Carcinomas//Cancer of the Pituitary//Pituitary Cancer//Cancer, Pituitary//Cancers, Pituitary//Cancer of Pituitary//Pituitary Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:336   
More Information
Causal ncRNA Number:32
Network:
Top Causal ncRNAs:
MEG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
LINC01004  (Score: 0.731059)
H19  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
CASC11  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
RPSAP52  (Score: 0.731059)
circVPS13C  (Score: 0.731059)
SNHG6  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Wound Healing Assay//qPCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31564894
Disease Name:Pituitary Neoplasms
Sample:PitNET tissues
Dysfunction Pattern:Interaction[increasing miR-424-5p]
Validated Method:RNA Pull-Down//Western Blot//Wound Healing Assay//qPCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Microarray//IHC//EdU Staining//Transwell Assay
Description:Both XIST and bFGF exhibited high expression, but miR-424-5p had a low expression in invasive PitNET tissues as compared to non-invasive PitNET normal pituitary tissues. In conclusion, the fundamental findings of the present study suggested that the functional suppression of XIST downregulated bFGF to inhibit the development of PitNET by increasing miR-424-5p expression, proposing XIST as a novel therapeutic target for PitNET.
Causality:Yes
Causal Description: Furthermore, depleted XIST or bFGF, or elevated miR-424-5p was revealed to suppress the proliferation, migration, invasion, and promote cell cycle arrest and apoptosis of invasive PitNET cells.
Clinical-realted Application: