Entry Detail

General Information

Database ID: LDA0006265
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:XIST
Full Name:X inactive specific transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:DXS1089|DXS399E|LINC00001|NCRNA00001|SXI1|swd66
Chromosome:X
Strand:-
Coordinate:
Start Site(bp):73820651End Site(bp):73852753
External Links:
Ensembl ID:ENSG00000229807
Ensembl Transcript ID:N/A
Entrez Gene:7503.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:84
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Stomach Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Retinoblastoma  (Score: 1)
Retinoblastoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3302D002817
Disease Name:chordomaChordoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A notochordal cancer that derives_from cellular remnants of the notochord.A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)
Alias:notochordomaChordoma//Chordomas

 

Disease Association Statistics

Total Associated ncRNA Number:10   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
XIST  (Score: 0.985791)
XIST  (Score: 0.985791)
RP11-867G2.8  (Score: 0.731059)
NONHSAT024778  (Score: 0.731059)
NONHSAT114552  (Score: 0.731059)
MDFIC-7  (Score: 0.731059)
RP11-867G2.8  (Score: 0.731059)
NONHSAT024778  (Score: 0.731059)
NONHSAT114552  (Score: 0.731059)
MDFIC-7  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//Colony Formation Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Cell Proliferation Assay//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32547104
Disease Name:Chordoma
Sample:chordoma tissues
Dysfunction Pattern:regulation[miR-124-3p/iASPP Pathway]
Validated Method:CCK8//qRT-PCR//Flow Cytometry
Description:We found that lncRNA XIST expression was upregulated in chordoma and strongly correlated with poor patient prognosis.Our findings demonstrate a key role for lncRNA XIST in chordoma progression by regulating miR124-3p/iAPSS pathway.
Causality:Yes
Causal Description:Moreover, lncRNA XIST promoted proliferation and inhibited apoptosis of chordoma cells.
Clinical-realted Application:We found that lncRNA XIST expression was upregulated in chordoma and strongly correlated with poor patient prognosis.

[2] PubMed ID:35899235
Disease Name:Chordoma
Sample:chordoma tissues
Dysfunction Pattern:Interaction( miR-320d/ARF6)
Validated Method:RNA Pull-Down//IHC//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay
Description:XIST was overexpressed in chordoma tissues. XIST acted as a sponge of miR-320d. Moreover, miR-320d overexpression inhibited the proliferation, migration, invasion, and glycolysis of chordoma cells. ARF6 was a direct target of miR-320d, and XIST upregulated ARF6 expression via sponging miR-320d. Furthermore, overexpression of ARF6 reversed the inhibitory effects of XIST knockdown on chordoma cell proliferation, migration, invasion, and glycolysis.
Causality:Yes
Causal Description: XIST knockdown suppressed chordoma cell proliferation, migration, invasion, and glycolysis.
Clinical-realted Application: