Entry Detail

General Information

Database ID: LDA0006268
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:XIST
Full Name:X inactive specific transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:DXS1089|DXS399E|LINC00001|NCRNA00001|SXI1|swd66
Chromosome:X
Strand:-
Coordinate:
Start Site(bp):73820651End Site(bp):73852753
External Links:
Ensembl ID:ENSG00000229807
Ensembl Transcript ID:N/A
Entrez Gene:7503.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:84
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Stomach Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Retinoblastoma  (Score: 1)
Retinoblastoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:299D000230
Disease Name:adenocarcinomaAdenocarcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue.A malignant epithelial tumor with a glandular organization.
Alias:Adenocarcinoma//Adenocarcinomas//Adenoma, Malignant//Adenomas, Malignant//Malignant Adenoma//Malignant Adenomas//Carcinoma, Granular Cell//Carcinomas, Granular Cell//Granular Cell Carcinoma//Granular Cell Carcinomas//Adenocarcinoma, Granular Cell//Adenocarcinomas, Granular Cell//Granular Cell Adenocarcinoma//Granular Cell Adenocarcinomas//Adenocarcinoma, Tubular//Adenocarcinomas, Tubular//Tubular Adenocarcinoma//Tubular Adenocarcinomas//Carcinoma, Tubular//Carcinomas, Tubular//Tubular Carcinoma//Tubular Carcinomas//Carcinoma, Cribriform//Carcinomas, Cribriform//Cribriform Carcinoma//Cribriform Carcinomas//Adenocarcinoma, Basal Cell//Adenocarcinomas, Basal Cell//Basal Cell Adenocarcinoma//Basal Cell Adenocarcinomas//Adenocarcinoma, Oxyphilic//Adenocarcinomas, Oxyphilic//Oxyphilic Adenocarcinoma//Oxyphilic Adenocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
XIST  (Score: 0.731059)
XIST  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31968395
Disease Name:Adenocarcinoma
Sample:LAD tissues and cells
Dysfunction Pattern:interaction[miR-363-3p]
Validated Method:RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Transwell Assay
Description:We found that XIST and MDM2 were remarkably elevated while miR-363-3p was reduced in LAD tissues and cells. XIST knockdown repressed proliferation, migration and invasion, and accelerated apoptosis of LAD cells by downregulating MDM2 expression via binding to miR-363-3p.
Causality:Yes
Causal Description: Both XIST and MDM2 downregulation restrained proliferation, migration and invasion, and facilitated apoptosis of LAD cells in vitro.
Clinical-realted Application: