Entry Detail

General Information

Database ID: LDA0006278
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:XIST
Full Name:X inactive specific transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:DXS1089|DXS399E|LINC00001|NCRNA00001|SXI1|swd66
Chromosome:X
Strand:-
Coordinate:
Start Site(bp):73820651End Site(bp):73852753
External Links:
Ensembl ID:ENSG00000229807
Ensembl Transcript ID:N/A
Entrez Gene:7503.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:84
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Stomach Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Retinoblastoma  (Score: 1)
Retinoblastoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10325D012829
Disease Name:silicosisSilicosis
Category:Disease OntologyMeSH
Type:Respiratory Tract Diseases
Define:A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.
Alias:Pneumoconiosis due to silicates//Silica pneumoconiosis//Silicotic fibrosis of lung//silicotuberculosisSilicosis//Silicoses

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
Snhg20  (Score: 0.731059)
hsa_circ_0058493  (Score: 0.731059)
XIST  (Score: 0.731059)
MRAK050699  (Score: 0.731059)
Snhg20  (Score: 0.731059)
hsa_circ_0058493  (Score: 0.731059)
XIST  (Score: 0.731059)
MRAK050699  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35271943
Disease Name:Silicosis
Sample:TGF-β1 stimulated lung epithelial cells
Dysfunction Pattern:Interaction(miR-101-3p/ZEB1 axis)
Validated Method:Western Blot//Transfection//qRT-PCR//FISH//Luciferase Report Assay
Description: The results reveal that LncRNA XIST and ZEB1 are up-regulated while the miR-101-3p expression is down-regulated in vivo and vitro models. Moreover, the results also illustrate that LncRNA XIST is mainly localized in the cytoplasm used FISH and possesses binding site with miR-101-3p which was identified as the target of ZEB1 used bioinformatics prediction website and Dual-luciferase reporter assay. The above demonstrated that LncRNA-XIST regulates ZEB1 by directly sponging miR-101-3p.
Causality:Yes
Causal Description: Furthermore, the knockdown of LncRNA XIST prevents the EMT process and the inhibition of miR-101-3p markedly promotes EMT stimulated by TGF-β1.
Clinical-realted Application: