Entry Detail

General Information

Database ID: LDA0006326
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ZEB1-AS1
Full Name:ZEB1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:10
Strand:-
Coordinate:
Start Site(bp):31307717End Site(bp):31320447
External Links:
Ensembl ID:ENSG00000237036
Ensembl Transcript ID:N/A
Entrez Gene:220930.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999358)
Colorectal Neoplasms  (Score: 0.999358)
Urinary Bladder Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Melanoma  (Score: 0.959542)
Melanoma  (Score: 0.959542)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D002689
Disease Name:Chlamydia
Category:MeSH
Type:Bacteria
Define:A genus of the family CHLAMYDIACEAE whose species cause a variety of diseases in vertebrates including humans, mice, and swine. Chlamydia species are gram-negative and produce glycogen. The type species is CHLAMYDIA TRACHOMATIS.
Alias:Chlamydia

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
ZEB1-AS1  (Score: 0.731059)
ZEB1-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:35266440
Disease Name:Chlamydia
Sample:cells
Dysfunction Pattern:Interaction(miR-1224-5p / MAP4K4 axis)
Validated Method:Western Blot//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Bioinformatics Analysis//IF
Description: ZEB1-AS1 is a long non-coding RNA (lncRNA), which was up-regulated in persistent C. trachomatis infection in our previous work. Mechanically, interference ZEB1-AS1 caused an apparent down-regulation of the Bcl-2/Bax ratio and the repression of the mitochondrial membrane potential with the remarkable release of cytochrome c, resulting in the significant elevation level of caspase-3 activation. Meanwhile, the luciferase reporter assay confirmed that ZEB1-AS1 acted as a sponge for miR-1224-5p to target MAP4K4.
Causality:Yes
Causal Description:The results showed that ZEB1-AS1 was involved in the regulation of apoptosis, and targeted silencing of ZEB1-AS1 could increase the apoptosis rate of persistently infected cells.
Clinical-realted Application: