Entry Detail

General Information

Database ID: LDA0006350
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:XIST
Full Name:X inactive specific transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:DXS1089|DXS399E|LINC00001|NCRNA00001|SXI1|swd66
Chromosome:X
Strand:-
Coordinate:
Start Site(bp):73820651End Site(bp):73852753
External Links:
Ensembl ID:ENSG00000229807
Ensembl Transcript ID:N/A
Entrez Gene:7503.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:84
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Stomach Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Retinoblastoma  (Score: 1)
Retinoblastoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077216
Disease Name:Carcinoma, Ovarian Epithelial
Category:MeSH
Type:Neoplasms
Define:A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer.
Alias:Carcinoma, Ovarian Epithelial//Epithelial Carcinoma, Ovarian//Ovarian Epithelial Carcinomas//Epithelial Ovarian Cancer//Ovarian Epithelial Cancer//Cancer, Ovarian Epithelial//Epithelial Cancer, Ovarian//Ovarian Epithelial Cancers//Ovarian Cancer, Epithelial//Cancer, Epithelial Ovarian//Epithelial Ovarian Cancers//Ovarian Epithelial Carcinoma//Epithelial Ovarian Carcinoma//Carcinoma, Epithelial Ovarian//Epithelial Ovarian Carcinomas//Ovarian Carcinoma, Epithelial

 

Disease Association Statistics

Total Associated ncRNA Number:102   
More Information
Causal ncRNA Number:80
Network:
Top Causal ncRNAs:
HIF1A-AS2  (Score: 0.985791)
HIF1A-AS2  (Score: 0.985791)
circN4BP2L2  (Score: 0.985791)
circBNC2  (Score: 0.985791)
circBNC2  (Score: 0.985791)
circN4BP2L2  (Score: 0.985791)
hsa_circ_0072995  (Score: 0.731059)
circATP2B4  (Score: 0.731059)
HOXB-AS3  (Score: 0.731059)
circRHOBTB3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31564909
Disease Name:Carcinoma, Ovarian Epithelial
Sample:EOC tissues and cell lines
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:XIST was up-regulated in EOC tissues and cell lines.
Causality:Yes
Causal Description: In in vitro experiments, reducing XIST expression significantly suppressed cell proliferation, migration and invasion in EOC cells.
Clinical-realted Application:The expression of XIST was closely related to the tumor grade, distant metastasis, and FIGO stage in the EOC patients. The Cox regression analysis showed that high XIST expression was an independent predictor of prognosis in patients with EOC.