Entry Detail

General Information

Database ID: LDA0006377
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SOD2
Full Name:superoxide dismutase 2
Category:LncRNA
Species:Homo sapiens
Synonyms:GC1|GClnc1|IPO-B|IPOB|MNSOD|MVCD6|Mn-SOD
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):159669069End Site(bp):159762281
External Links:
Ensembl ID:ENSG00000291237
Ensembl Transcript ID:N/A
Entrez Gene:6648.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077216
Disease Name:Carcinoma, Ovarian Epithelial
Category:MeSH
Type:Neoplasms
Define:A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer.
Alias:Carcinoma, Ovarian Epithelial//Epithelial Carcinoma, Ovarian//Ovarian Epithelial Carcinomas//Epithelial Ovarian Cancer//Ovarian Epithelial Cancer//Cancer, Ovarian Epithelial//Epithelial Cancer, Ovarian//Ovarian Epithelial Cancers//Ovarian Cancer, Epithelial//Cancer, Epithelial Ovarian//Epithelial Ovarian Cancers//Ovarian Epithelial Carcinoma//Epithelial Ovarian Carcinoma//Carcinoma, Epithelial Ovarian//Epithelial Ovarian Carcinomas//Ovarian Carcinoma, Epithelial

 

Disease Association Statistics

Total Associated ncRNA Number:102   
More Information
Causal ncRNA Number:80
Network:
Top Causal ncRNAs:
HIF1A-AS2  (Score: 0.985791)
HIF1A-AS2  (Score: 0.985791)
circN4BP2L2  (Score: 0.985791)
circBNC2  (Score: 0.985791)
circBNC2  (Score: 0.985791)
circN4BP2L2  (Score: 0.985791)
hsa_circ_0072995  (Score: 0.731059)
circATP2B4  (Score: 0.731059)
HOXB-AS3  (Score: 0.731059)
circRHOBTB3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:ISH//qRT-PCR//FISH
Weak Evidence:

 

Reference

[1] PubMed ID:33338479
Disease Name:Carcinoma, Ovarian Epithelial
Sample:EOC tissues
Dysfunction Pattern:regulation[recruiting FOXC2,activating the NF-κB/Snail signaling ]
Validated Method:ISH//qRT-PCR//FISH
Description: GClnc1 was significantly overexpressed in EOC tissues,GClnc1 promoted NOTCH1 transcription by recruiting FOXC2, thereby activating the NF-κB/Snail signaling and promoting EOC cell growth and metastasis.
Causality:Yes
Causal Description:GClnc1 was significantly overexpressed in EOC tissues, and knockdown of GClnc1 inhibited cell viability and promoted apoptosis.Finally, in vivo experiments demonstrated that GClnc1 knockdown suppressed the growth and metastasis of SKOV3 and OVC1 cells in vivo.
Clinical-realted Application: