Entry Detail

General Information

Database ID: LDA0006385
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SOCS2-AS1
Full Name:SOCS2 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):93565628End Site(bp):93571398
External Links:
Ensembl ID:ENSG00000246985
Ensembl Transcript ID:N/A
Entrez Gene:144481.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Mucocutaneous Lymph Node Syndrome  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Mucocutaneous Lymph Node Syndrome  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:13378D009080
Disease Name:Kawasaki diseaseMucocutaneous Lymph Node Syndrome
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels located_in body, has_symptom fever, has_symptom congestion of ocular conjunctivae, has_symptom reddening of lips, has_symptom reddening of oral cavity, has_symptom protuberance of tongue papillae and has_symptom edema of extremities.An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
Alias:Kawasaki's disease//MLNS//acute febrile MCLS//acute febrile mucocutaneous lymph node syndrome//mucocutaneous lymph node syndromeMucocutaneous Lymph Node Syndrome//Kawasaki Syndrome//Lymph Node Syndrome, Mucocutaneous//Kawasaki Disease

 

Disease Association Statistics

Total Associated ncRNA Number:18   
More Information
Causal ncRNA Number:6
Network:
Top Causal ncRNAs:
SLCO4A1  (Score: 0.731059)
SOCS2-AS1  (Score: 0.731059)
hsa_circ_3302  (Score: 0.731059)
SLCO4A1  (Score: 0.731059)
SOCS2-AS1  (Score: 0.731059)
hsa_circ_3302  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//CCK8//RIP//Flow Cytometry//qRT-PCR//Luciferase Report Assay//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:32688371
Disease Name:Mucocutaneous Lymph Node Syndrome
Sample:blood
Dysfunction Pattern:regulation[SOCS2-AS1/miR-324-5p/CUEDC2 axis ]
Validated Method:RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//EdU Staining
Description:SOCS2-AS1 was highly expressed in serum and tissues of KD patients.SOCS2-AS1 upregulates CUEDC2 via inhibiting miR-324-5p to promote the progression of HUVECs in KD, providing new insights for KD treatment.
Causality:Yes
Causal Description:SOCS2-AS1 depletion repressed the proliferation of HUVECs, whereas it facilitated apoptosis.
Clinical-realted Application: