Entry Detail

General Information

Database ID: LDA0006526
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG5
Full Name:small nucleolar RNA host gene 5
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf160|LINC00044|NCRNA00044|U50HG
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):85677007End Site(bp):85678733
External Links:
Ensembl ID:ENSG00000203875
Ensembl Transcript ID:ENSG00000203875
Entrez Gene:387066.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:44
Network:
Top Causal Diseases:
Glioma  (Score: 0.999893)
Glioma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.731059)
Melanoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8577D003093
Disease Name:ulcerative colitisColitis, Ulcerative
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
Alias:Left-sided ulcerative colitisColitis, Ulcerative//Idiopathic Proctocolitis//Ulcerative Colitis//Colitis Gravis//Inflammatory Bowel Disease, Ulcerative Colitis Type

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
H19  (Score: 0.985791)
H19  (Score: 0.985791)
hsa_circ_0001187  (Score: 0.731059)
Tug1  (Score: 0.731059)
SNHG5  (Score: 0.731059)
NORAD  (Score: 0.731059)
Meg3  (Score: 0.731059)
MEG3  (Score: 0.731059)
hsa_circ_0001187  (Score: 0.731059)
Tug1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:34334085
Disease Name:Colitis, Ulcerative
Sample:intestinal mucosa tissues
Dysfunction Pattern:Interaction(microRNA-375 / Janus kinase-2 axis)
Validated Method:Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//EdU Staining
Description: SNHG5 was up-regulated in intestinal mucosa tissues of UC patients as well as tumor necrosis factor alpha-treated (TNF-α-treated) young adult mouse colon (YAMC) cells. Additionally, miR-375 targeted JAK2, which was up-regulated by TNF-α treated YAMC cells. Up-regulation of JAK2 induced the dysfunction of YAMC cells. Knockdown of SNHG5 promoted the proliferation and suppressed the apoptosis of YAMC cells via regulating miR-375/JAK2 axis. Therefore, knockdown of SNHG5 may be a promising therapy for UC.
Causality:Yes
Causal Description:Down-regulated SNHG5 promoted cell proliferation and inhibited apoptosis of YAMC cells. miR-375 was verified to be a target of SNHG5 and was suppressed by TNF-α treatment in YAMC cells. Over-expression of miR-375 restored YAMC cellular functions.
Clinical-realted Application: