Entry Detail

General Information

Database ID: LDA0006534
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG5
Full Name:small nucleolar RNA host gene 5
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf160|LINC00044|NCRNA00044|U50HG
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):85677007End Site(bp):85678733
External Links:
Ensembl ID:ENSG00000203875
Ensembl Transcript ID:ENSG00000203875
Entrez Gene:387066.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:44
Network:
Top Causal Diseases:
Glioma  (Score: 0.999893)
Glioma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.731059)
Melanoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:7693D017544
Disease Name:abdominal aortic aneurysmAortic Aneurysm, Abdominal
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An aortic aneurysm that is located_in the abdominal aorta.An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
Alias:AORTIC ANEURYSM, FAMILIAL ABDOMINAL 1Aortic Aneurysm, Abdominal//Abdominal Aortic Aneurysms//Aneurysm, Abdominal Aortic//Abdominal Aortic Aneurysm//Abdominal Aorta Aneurysm//Abdominal Aorta Aneurysms//Aorta Aneurysm, Abdominal//Aneurysm, Abdominal Aorta

 

Disease Association Statistics

Total Associated ncRNA Number:22   
More Information
Causal ncRNA Number:22
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.731059)
H20  (Score: 0.731059)
Gas5  (Score: 0.731059)
SENCR  (Score: 0.731059)
SBF2-AS1  (Score: 0.731059)
RBM33  (Score: 0.731059)
SNHG5  (Score: 0.731059)
TP53COR1  (Score: 0.731059)
hsa_circ_0087352  (Score: 0.731059)
H19  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34185955
Disease Name:Aortic Aneurysm, Abdominal
Sample:(GEO)49 AAA patients and 10 control aortic specimens
Dysfunction Pattern:Interaction(mir‐205‐5p/SMAD4)
Validated Method:Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay
Description: SNHG5 was downregulated in the AAA and acts as a molecular sponge for mir‐205. Downregulation of SNHG5 induces expression of mir‐205‐5p. Increased mir‐205‐5p expression level inhibits SMAD4 production, thus inhibiting proliferation and migration and promotes apoptosis of smooth muscle cells.
Causality:Yes
Causal Description: Increased mir‐205‐5p expression level inhibits SMAD4 production, thus inhibiting proliferation and migration and promotes apoptosis of smooth muscle cells.
Clinical-realted Application: