Entry Detail

General Information

Database ID: LDA0006537
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG5
Full Name:small nucleolar RNA host gene 5
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf160|LINC00044|NCRNA00044|U50HG
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):85677007End Site(bp):85678733
External Links:
Ensembl ID:ENSG00000203875
Ensembl Transcript ID:ENSG00000203875
Entrez Gene:387066.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:44
Network:
Top Causal Diseases:
Glioma  (Score: 0.999893)
Glioma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.731059)
Melanoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D012128
Disease Name:Respiratory Distress Syndrome
Category:MeSH
Type:Respiratory Tract Diseases
Define:A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
Alias:Respiratory Distress Syndrome//Distress Syndrome, Respiratory//Distress Syndromes, Respiratory//Respiratory Distress Syndromes//Syndrome, Respiratory Distress//Shock Lung//Lung, Shock//Respiratory Distress Syndrome, Acute//Acute Respiratory Distress Syndrome//ARDS, Human//Human ARDS//Respiratory Distress Syndrome, Pediatric//Pediatric Respiratory Distress Syndrome//Respiratory Distress Syndrome, Adult//Adult Respiratory Distress Syndrome

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
H19  (Score: 0.731059)
SNHG5  (Score: 0.731059)
H19  (Score: 0.731059)
SNHG5  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//MTT//Luciferase Report Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:33170429
Disease Name:Respiratory Distress Syndrome
Sample:blood
Dysfunction Pattern:regulation[miR-205/COMMD1 axis]
Validated Method:qRT-PCR//MTT//Luciferase Report Assay//Western Blot
Description:SNHG5 was downregulated, while miR-205 was upregulated in the serum of ARDS patients and lung tissues of LPS-induced mice.SNHG5 acted as a sponge for miR-205 to ameliorate LPS-induced ARDS by regulating COMMD1.
Causality:Yes
Causal Description:Upregulation of SNHG5 or down-regulation of miR-205 inhibited inflammation and promoted the viability of LPS-induced A549 cells.
Clinical-realted Application: