Entry Detail

General Information

Database ID: LDA0006541
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG5
Full Name:small nucleolar RNA host gene 5
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf160|LINC00044|NCRNA00044|U50HG
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):85677007End Site(bp):85678733
External Links:
Ensembl ID:ENSG00000203875
Ensembl Transcript ID:ENSG00000203875
Entrez Gene:387066.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:44
Network:
Top Causal Diseases:
Glioma  (Score: 0.999893)
Glioma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.731059)
Melanoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9191
Disease Name:diabetic macular edema
Category:Disease Ontology
Type:Endocrine System Diseases
Define:
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
SNHG5  (Score: 0.731059)
SNHG5  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:35001073
Disease Name:diabetic macular edema
Sample:atrial fluid and plasma
Dysfunction Pattern:Expression(lower expressed)
Validated Method:CCK8//qRT-PCR//Western Blot
Description:SNHG5 expression was not only low in the atrial fluid and plasma in DME patients, but also lower in the refractory DME group compared to the idiopathic MH patients.
Causality:Yes
Causal Description: In the in vitro experiments, SNHG5 expression was significantly downregulated in high glucose-induced HMECs. After SNHG5 overexpression, cell proliferation, angiogenesis, and VEGF-A protein levels were distinctly downregulated.
Clinical-realted Application: SNHG5 expression in the aqueous humor and plasma was negatively correlated with disease duration, body mass index, and levels of fasting blood glucose, glycated hemoglobin, proteinuria, and glycosuria.