Entry Detail

General Information

Database ID: LDA0006543
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG4
Full Name:small nucleolar RNA host gene 4
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00059|U19H
Chromosome:5
Strand:+
Coordinate:
Start Site(bp):139274101End Site(bp):139284900
External Links:
Ensembl ID:ENSG00000281398
Ensembl Transcript ID:N/A
Entrez Gene:724102.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:24
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Leukemia, Myeloid, Acute  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:1648   
More Information
Causal ncRNA Number:1044
Network:
Top Causal ncRNAs:
NORAD  (Score: 1)
SNHG1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MALAT1  (Score: 1)
SNHG12  (Score: 1)
DLX6-AS1  (Score: 1)
UCA1  (Score: 1)
SNHG3  (Score: 1)
H19  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33567852
Disease Name:Stomach Neoplasms
Sample:GC cells
Dysfunction Pattern:Interaction(miR-204-5p)
Validated Method:In Vivo Experiment//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay
Description:. The results showed that SNHG4 expression in GC cells was at a higher level compared to normal gastric mucosal epithelial cells. Dual-luciferase reporter assay results showed that miR-204-5p was a direct target of SNHG4.
Causality:Yes
Causal Description: Knockdown of SNHG4 dramatically suppressed proliferation, migration and invasion, and blocked cell cycle progression of GC cells. Moreover, knockdown of SNHG4 upregulated microRNA-204-5p (miR-204-5p) expression, whereas downregulated ribonucleotide reductase subunit M2 (RRM2) expression in GC cells. Additionally, knockdown of SNHG4 suppressed GC tumorigenesis in xenograft mouse models.
Clinical-realted Application:

[2] PubMed ID:33236157
Disease Name:Stomach Neoplasms
Sample:GC tissues and cell lines
Dysfunction Pattern:interaction[sponging miR-204-5p]
Validated Method:Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay
Description:The results demonstrated that in GC tissues and cell lines.The findings of the current study revealed the potential mechanism of the SNHG4‑miR‑204‑5p pathway in GC, which may be conducive to the development of novel drugs against GC growth.
Causality:Yes
Causal Description: The downregulated expression of SNHG4 decreased the effects of miR‑204‑5p inhibitor on promoting cell proliferation, migration, invasion and epithelial‑mesenchymal transition, but enhanced the inhibitory effect of miR‑204‑5p on GC cell apoptosis.
Clinical-realted Application:SNHG4 was highly expressed