Entry Detail

General Information

Database ID: LDA0006545
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG6
Full Name:small nucleolar RNA host gene 6
Category:LncRNA
Species:Homo sapiens
Synonyms:HBII-276HG|NCRNA00058|U87HG
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):66921690End Site(bp):66925541
External Links:
Ensembl ID:ENSG00000245910
Ensembl Transcript ID:N/A
Entrez Gene:641638.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:56   
More Information
Causal Disease Number:46
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Esophageal Squamous Cell Carcinoma  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Esophageal Squamous Cell Carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050934
Disease Name:ovarian clear cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:An ovarian carcinoma that has_material_basis_in cells with clear cytoplasm and glycogen secreting hob nail cells.
Alias:clear-cell ovarian carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
GAS5  (Score: 0.731059)
SNHG6  (Score: 0.731059)
GAS5  (Score: 0.731059)
SNHG6  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31119871
Disease Name:ovarian clear cell carcinoma
Sample:ovarian tissues
Dysfunction Pattern:Interaction[sponging miR-4465]
Validated Method:Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay
Description:In the present study, we showed via quantitative real-time PCR that SNHG6 expression was abnormally up-regulated in OCCC tissues relative to that in unpaired normal ovarian tissues. Moreover, SNHG6 functioned as a competing endogenous RNA (ceRNA), effectively acting as a sponge for miR-4465 and thereby modulating the expression of enhancer of zeste homolog 2 (EZH2).
Causality:Yes
Causal Description:Further functional experiments demonstrated that knockdown of SNHG6 in OCCC cells inhibited cell proliferation, migration and invasion in vitro as well as tumour growth in vivo.
Clinical-realted Application:High SNHG6 expression was correlated with vascular invasion, distant metastasis and poor survival.