Entry Detail

General Information

Database ID: LDA0006551
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG6
Full Name:small nucleolar RNA host gene 6
Category:LncRNA
Species:Homo sapiens
Synonyms:HBII-276HG|NCRNA00058|U87HG
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):66921690End Site(bp):66925541
External Links:
Ensembl ID:ENSG00000245910
Ensembl Transcript ID:N/A
Entrez Gene:641638.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:56   
More Information
Causal Disease Number:46
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Esophageal Squamous Cell Carcinoma  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Esophageal Squamous Cell Carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3371D002813
Disease Name:chondrosarcomaChondrosarcoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A bone sarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage.A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
Alias:Cartilaginous cancer//chondrosarcoma of bone//primary chondrosarcoma of the boneChondrosarcoma//Chondrosarcomas

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
SNHG6  (Score: 0.731059)
SNHG6  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Transfection//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//H&E Staining//Colony Formation Assay//Invasion Assay//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:33431838
Disease Name:Chondrosarcoma
Sample:chondrosarcoma tissues
Dysfunction Pattern:Expression [highly expressed]
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Colony Formation Assay//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//H&E Staining//IHC//Invasion Assay//ChIP
Description:Here we found that SNHG6 expression was upregulated and showed positive correlation with the progression of chondrosarcoma. Mechanistic study revealed that SNHG6 could recruit EZH2 and maintain high level of H3K27me3 to repress the transcription of tumor-suppressor genes, including KLF6. KLF6 was found to bind to the promoter region of SP1 and restrained its transcription, while SP1 could be recruited to the promoter region of SNHG6 and promoted its transcription to form a positive loop.
Causality:Yes
Causal Description:Functional assays demonstrated that SNHG6 was required for the proliferation, migration, and invasion of chondrosarcoma cells.
Clinical-realted Application: