Entry Detail

General Information

Database ID: LDA0006591
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG7
Full Name:small nucleolar RNA host gene 7
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00061
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):136724594End Site(bp):136728184
External Links:
Ensembl ID:ENSG00000233016
Ensembl Transcript ID:N/A
Entrez Gene:84973.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:48
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Urinary Bladder Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Neuroblastoma  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9261C538339
Disease Name:nasopharynx carcinomaNasopharyngeal carcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.A carcinoma that originates in the nasopharyngeal EPITHELIUM and includes 4 subtypes: keratinizing squamous cell, nonkeratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes. OMIM: 607107
Alias:Nasopharyngeal carcinoma//malignant Nasopharyngeal tumor//malignant neoplasm of nasopharynx//nasopharynx cancer

 

Disease Association Statistics

Total Associated ncRNA Number:260   
More Information
Causal ncRNA Number:244
Network:
Top Causal ncRNAs:
ZFAS1  (Score: 1)
ZFAS1  (Score: 1)
DANCR  (Score: 0.999893)
XIST  (Score: 0.999893)
XIST  (Score: 0.999893)
DANCR  (Score: 0.999893)
circZNF609  (Score: 0.985791)
hsa_circ_0008450  (Score: 0.985791)
PVT1  (Score: 0.985791)
circZNF609  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:32370736
Disease Name:Nasopharyngeal carcinoma
Sample:NPC cells
Dysfunction Pattern:regulation[miR-514a-5p/ELAVL1 axis]
Validated Method:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining
Description:SNHG7 was upregulated in NPC cells, and absence of SNHG7 suppressed cell proliferation as well as promoted cell apoptosis in NPC. LncRNA SNHG7 promotes the proliferation and migration of nasopharyngeal carcinoma by miR-514a-5p/ ELAVL1 axis.
Causality:Yes
Causal Description:In the end, rescue assays demonstrated that the miR-514a-5p deficiency restored the NPC progression inhibited by SNHG7 silence, and ELAVL1 partly counteracted the restoration caused by miR-514a-5p inhibitor in HNE1 cells.
Clinical-realted Application: