Entry Detail

General Information

Database ID: LDA0006604
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG8
Full Name:small nucleolar RNA host gene 8
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00060|NCRNA00060
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):118278762End Site(bp):118279823
External Links:
Ensembl ID:ENSG00000269893
Ensembl Transcript ID:ENSG00000269893
Entrez Gene:100093630.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.999358)
Breast Neoplasms  (Score: 0.999358)
Nasopharyngeal carcinoma  (Score: 0.985791)
Nasopharyngeal carcinoma  (Score: 0.985791)
Osteosarcoma  (Score: 0.731059)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.731059)
Parkinson Disease  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5844D009203
Disease Name:myocardial infarctionMyocardial Infarction
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Alias:Myocardial infarct//heart attackMyocardial Infarction//Infarction, Myocardial//Infarctions, Myocardial//Myocardial Infarctions//Cardiovascular Stroke//Cardiovascular Strokes//Stroke, Cardiovascular//Strokes, Cardiovascular//Myocardial Infarct//Infarct, Myocardial//Infarcts, Myocardial//Myocardial Infarcts//Heart Attack//Heart Attacks

 

Disease Association Statistics

Total Associated ncRNA Number:80   
More Information
Causal ncRNA Number:68
Network:
Top Causal ncRNAs:
TUG1  (Score: 0.999893)
TUG1  (Score: 0.999893)
Miat  (Score: 0.959542)
Miat  (Score: 0.959542)
lncRNA93358  (Score: 0.731059)
LNC_554  (Score: 0.731059)
LncRNAMORT  (Score: 0.731059)
Malat1  (Score: 0.731059)
CAIF  (Score: 0.731059)
POSTN  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//qPCR//RIP//MTT//H&E Staining//ELISA//IHC
Weak Evidence:

 

Reference

[1] PubMed ID:36282350
Disease Name:Myocardial Infarction
Sample:myocardial tissue
Dysfunction Pattern:Interaction(PTBP1/ALAS2 )
Validated Method:RNA Pull-Down//Western Blot//Transfection//qPCR//RIP//MTT//H&E Staining//ELISA//IHC
Description: lncRNA-SNHG8 knockdown in MI mice was reduced myocardial infarction size, alleviated myocardial tissue injury and oxidative stress, and inhibited ALAS2 expression in myocardial tissue. RNA pulldown and RIP assays showed that lncRNA-SNHG8 binged with PTBP1 and PTBP1 interacted with ALAS2 mRNA.
Causality:Yes
Causal Description:Knockdown of lncRNA-SNHG8, METTL3 or PTBP1 in MI cells enhanced viability of myocardial cells, attenuated ROS release and MDA level, increased SOD level, alleviated oxidative stress. ALAS overexpression attenuated the corresponding effect of knockdown of lncRNA-SNHG8 and/or PTBP1 on MI cells.
Clinical-realted Application: