Entry Detail

General Information

Database ID: LDA0006605
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG8
Full Name:small nucleolar RNA host gene 8
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00060|NCRNA00060
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):118278762End Site(bp):118279823
External Links:
Ensembl ID:ENSG00000269893
Ensembl Transcript ID:ENSG00000269893
Entrez Gene:100093630.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.999358)
Breast Neoplasms  (Score: 0.999358)
Nasopharyngeal carcinoma  (Score: 0.985791)
Nasopharyngeal carcinoma  (Score: 0.985791)
Osteosarcoma  (Score: 0.731059)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.731059)
Parkinson Disease  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050745D016403
Disease Name:diffuse large B-cell lymphomaLymphoma, Large B-Cell, Diffuse
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body.Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Alias:Lymphoma, Large B-Cell, Diffuse//Lymphoma, Histiocytic//Histiocytic Lymphomas//Lymphoma, Large Lymphoid, Diffuse//Lymphoma, Histiocytic, Diffuse//Lymphoma, Large Cell, Diffuse//Lymphoma, Diffuse Large-Cell//Lymphoma, Diffuse Large Cell//Diffuse Large-Cell Lymphoma//Diffuse Large Cell Lymphoma//Diffuse Large-Cell Lymphomas//Diffuse, Large B-Cell, Lymphoma//Histiocytic Lymphoma//Histiocytic Lymphoma, Diffuse//Diffuse Histiocytic Lymphoma//Diffuse Histiocytic Lymphomas//Lymphoma, Diffuse Histiocytic//Large Lymphoid Lymphoma, Diffuse//Large-Cell Lymphoma, Diffuse//Large Cell Lymphoma, Diffuse//Diffuse Large B-Cell Lymphoma//Diffuse Large B Cell Lymphoma//Lymphoma, Large-Cell, Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:58   
More Information
Causal ncRNA Number:54
Network:
Top Causal ncRNAs:
FIRRE  (Score: 0.985791)
NEAT1  (Score: 0.985791)
SNHG14  (Score: 0.985791)
MALAT1  (Score: 0.985791)
FIRRE  (Score: 0.985791)
NEAT1  (Score: 0.985791)
SNHG14  (Score: 0.985791)
MALAT1  (Score: 0.985791)
circPCBP2  (Score: 0.731059)
circAPC  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33816305
Disease Name:Lymphoma, Large B-Cell, Diffuse
Sample:DLBCL tissues and cells
Dysfunction Pattern:Interaction(miR-335-5p)
Validated Method:Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Description:The expression of SNHG8 was evaluated in several DLBCL cell lines and a normal lymphocyte cell line. It was found that SNHG8 was overexpressed in DLBCL tissues and cells in comparison with their normal counterparts. MiR-335-5p was predicted to be a potential target of SNHG8 by using the bioinformatics analysis, and the interaction between the two was validated by using the dual luciferase assay. In addition, the knockdown of SNHG8 increased the level of miR-335-5p, whereas miR-335-5p mimic decreased the expression of SNHG8.
Causality:Yes
Causal Description:The results showed that the knockdown of SNHG8 significantly inhibited DLBCL cell proliferation and colony formation while promoting cell apoptosis. Moreover, the knockdown of SNHG8 reduced the expression of Ki-67, proliferating cell nuclear antigen (PCNA), and Bcl-2 and enhanced the expression of Bax and cleaved caspase 3/9.
Clinical-realted Application: