Entry Detail

General Information

Database ID: LDA0006611
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG7
Full Name:small nucleolar RNA host gene 7
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00061
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):136724594End Site(bp):136728184
External Links:
Ensembl ID:ENSG00000233016
Ensembl Transcript ID:N/A
Entrez Gene:84973.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:48
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Urinary Bladder Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Neuroblastoma  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:769D009447
Disease Name:neuroblastomaNeuroblastoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An autonomic nervous system neoplasm that derives_from immature nerve cells.A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Alias:Neuroblastoma//Neuroblastomas

 

Disease Association Statistics

Total Associated ncRNA Number:98   
More Information
Causal ncRNA Number:60
Network:
Top Causal ncRNAs:
SNHG16  (Score: 1)
SNHG16  (Score: 1)
DUXAP9  (Score: 0.999893)
DLX6-AS1  (Score: 0.999893)
DLX6-AS1  (Score: 0.999893)
DUXAP9  (Score: 0.999893)
LINC00839  (Score: 0.985791)
SNHG7  (Score: 0.985791)
SNHG7  (Score: 0.985791)
LINC00839  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//RIP//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30623419
Disease Name:Neuroblastoma
Sample:NB tissues
Dysfunction Pattern:Interaction[miR-653-5p/STAT2 pathway]
Validated Method:qRT-PCR
Description:Our study revealed that SNHG7 expression was markedly higher in NB tissues than that in nontumor tissues. Jointly, our findings elucidated SNHG7 facilitated NB progression through the miR-653-5p/STAT2 pathway, providing a novel therapeutic target and prognostic biomarker for this disease.
Causality:Yes
Causal Description: Functionally, the loss-of-function assays demonstrated that knockdown of SNHG7 inhibited cell proliferation, migration, invasion, and epithelial-mesenchymal transition in NB cells.
Clinical-realted Application:Besides, upregulated SNHG7 was greatly correlated with poor overall survival of NB patients.

[2] PubMed ID:32534305
Disease Name:Neuroblastoma
Sample:NB tissues and cell lines
Dysfunction Pattern:interaction[sponging miR-323a-5p and miR-342-5p]
Validated Method:qRT-PCR//Luciferase Report Assay//RIP//Transwell Assay
Description: We found that SNHG7 was upregulated in NB tissues and cell lines, and high SNHG7 level was relevant to poor prognosis of NB patients.In conclusion, our study suggested that SNHG7 silencing hindered NB progression at least partly though sponging miR-323a-5p and miR-342-5p, illuminating its potential value as a therapeutic target.
Causality:Yes
Causal Description:SNHG7 silencing resulted in the repression of NB cell migration, invasion and glycolysis.
Clinical-realted Application: We found that SNHG7 was upregulated in NB tissues and cell lines, and high SNHG7 level was relevant to poor prognosis of NB patients.