Entry Detail

General Information

Database ID: LDA0006621
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG7
Full Name:small nucleolar RNA host gene 7
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00061
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):136724594End Site(bp):136728184
External Links:
Ensembl ID:ENSG00000233016
Ensembl Transcript ID:N/A
Entrez Gene:84973.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:48
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Urinary Bladder Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Neuroblastoma  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:6039C536494
Disease Name:uveal melanomaUveal melanoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A uveal cancer that has_material_basis_in uvea pigment cells.A melanoma that originates from uveal MELANOCYTES and is the most common primary intraocular malignancy. Tumors consist of four cell types: epitheloid, intermediate, mixed, and spindle. Somatic mutations in BAP1, GNAQ, GNA11, EIF1AX, and SF3B1 genes have been identified. OMIM: 155720
Alias:melanoma of Uvea

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.985791)
PVT1  (Score: 0.985791)
GAS5  (Score: 0.731059)
LOC100132707  (Score: 0.731059)
CARD11  (Score: 0.731059)
hsa_circ_0119872  (Score: 0.731059)
SNHG7  (Score: 0.731059)
GAS5  (Score: 0.731059)
LOC100132707  (Score: 0.731059)
CARD11  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:32002036
Disease Name:Uveal melanoma
Sample:UM tissues and cell lines
Dysfunction Pattern:Interaction[downregulation of EZH2 ]
Validated Method:CCK8//qRT-PCR//Western Blot
Description:The results of the present study indicated that low expression of SNHG7 was associated with poor prognosis. Western blot analysis results revealed that overexpression of SNHG7 downregulated EZH2 protein expression levels in UM cell lines. The results of the present study demonstrated that SNHG7 inhibited malignant transformation of UM cells by regulating EZH2 expression.
Causality:Yes
Causal Description:Furthermore, increasing the expression of SNHG7 inhibited the proliferation of UM cells, suppressed cell cycle progression and promoted apoptosis.
Clinical-realted Application: