Entry Detail

General Information

Database ID: LDA0006622
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SNHG7
Full Name:small nucleolar RNA host gene 7
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00061
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):136724594End Site(bp):136728184
External Links:
Ensembl ID:ENSG00000233016
Ensembl Transcript ID:N/A
Entrez Gene:84973.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:48
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Urinary Bladder Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Neuroblastoma  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8947D003930
Disease Name:diabetic retinopathyDiabetic Retinopathy
Category:Disease OntologyMeSH
Type:Eye Diseases
Define:Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Alias:Retinal abnormality - diabetes-relatedDiabetic Retinopathy//Diabetic Retinopathies//Retinopathies, Diabetic//Retinopathy, Diabetic

 

Disease Association Statistics

Total Associated ncRNA Number:34   
More Information
Causal ncRNA Number:28
Network:
Top Causal ncRNAs:
ZNF503-AS1  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
FLG-AS1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
LINC00673  (Score: 0.731059)
SNHG16  (Score: 0.731059)
VEAL2  (Score: 0.731059)
MAP4K2  (Score: 0.731059)
TDRG1  (Score: 0.731059)
SNHG7  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Tube Formation Assay//qRT-PCR//Luciferase Report Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:33600866
Disease Name:Diabetic Retinopathy
Sample:HRMECs
Dysfunction Pattern:Interaction(miR-34a-5p/XBP1 axis)
Validated Method:RNA Pull-Down//Western Blot//Tube Formation Assay//qRT-PCR//Luciferase Report Assay//IF
Description: LncRNA SNHG7 sponged to and negatively regulated miR-34a-5p. SNHG7 overexpression repressed HG induced endothelial-mesenchymal transition (EndMT) and tube formation of HRMECs, while miR-34a-5p overexpression could reverse this effect. miR-34a-5p targeted and negative regulated XBP1.
Causality:Yes
Causal Description: LncRNA SNHG7 sponged to and negatively regulated miR-34a-5p. SNHG7 overexpression repressed HG induced endothelial-mesenchymal transition (EndMT) and tube formation of HRMECs, while miR-34a-5p overexpression could reverse this effect.
Clinical-realted Application: