Entry Detail

General Information

Database ID: LDA0006635
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TP73-AS1
Full Name:Gfo/Idh/MocA-like oxidoreductase domain containing 3, pseudogene
Category:LncRNA
Species:Homo sapiens
Synonyms:KIAA0495|PDAM|TP73-AS1
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):3735984End Site(bp):3747373
External Links:
Ensembl ID:ENSG00000227372
Ensembl Transcript ID:N/A
Entrez Gene:57212.0
NONCODE ID:NONHSAT226305
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:46   
More Information
Causal Disease Number:42
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Pancreatic Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3498
Disease Name:pancreatic ductal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic adenocarcinoma that derives_from pancreatic duct cells.
Alias:ductal adenocarcinoma of the pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:110
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
circMYOF  (Score: 0.731059)
circBFAR  (Score: 0.731059)
hsa_circ_000684  (Score: 0.731059)
circSLIT2  (Score: 0.731059)
hsa_circ_0005105  (Score: 0.731059)
circEYA3  (Score: 0.731059)
circNEIL3  (Score: 0.731059)
hsa_circ_0047744  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33683827
Disease Name:pancreatic ductal adenocarcinoma
Sample:PDAC tissues
Dysfunction Pattern:Interaction(miR-200a)
Validated Method:qRT-PCR//Luciferase Report Assay
Description: In this study, we identified a novel host factor, namely the LncRNA TP73-AS1, as overexpressed in PDAC tissues compared to adjacent healthy tissue samples. Mechanistically, we found that TP73-AS1 suppressed the expression of the known oncogenic miR-200a. Taken together, these data highlight the prognostic potential of TP73-AS1 for PC patients and highlight it as a potential anti-PDAC therapeutic target.
Causality:Yes
Causal Description:To reveal its role in PDCA, we targeted TP73-AS1 using LnRNA inhibitors in a range of pancreatic cancer (PC) cell lines. We found that the inhibition of TP73-AS1 led to a loss of MMP14 expression in PC cells and significantly inhibited their migratory and invasive capacity. No effects of TP73-AS1 on cell survival or proliferation were observed.
Clinical-realted Application:The overexpression of TP-73-AS1 was found to correlate with both PDAC stage and lymph node metastasis.