Entry Detail

General Information

Database ID: LDA0006690
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TP53COR1
Full Name:tumor protein p53 pathway corepressor 1
Category:LncRNA
Species:Homo sapiens
Synonyms:TRP53COR1|linc-p21|lincRNA-p21
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:102800311.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:28   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Atherosclerosis  (Score: 0.731059)
Diabetes Mellitus, Type 2  (Score: 0.731059)
Aortic Aneurysm, Abdominal  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9352D003924
Disease Name:type 2 diabetes mellitusDiabetes Mellitus, Type 2
Category:Disease OntologyMeSH
Type:Nutritional and Metabolic Diseases
Define:A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Alias:NIDDM//non-insulin-dependent diabetes mellitus//type 2 diabetes//type II diabetes mellitusDiabetes Mellitus, Type 2//Diabetes Mellitus, Noninsulin-Dependent//Diabetes Mellitus, Ketosis-Resistant//Diabetes Mellitus, Ketosis Resistant//Ketosis-Resistant Diabetes Mellitus//Diabetes Mellitus, Non Insulin Dependent//Diabetes Mellitus, Non-Insulin-Dependent//Non-Insulin-Dependent Diabetes Mellitus//Diabetes Mellitus, Stable//Stable Diabetes Mellitus//Diabetes Mellitus, Type II//NIDDM//Diabetes Mellitus, Noninsulin Dependent//Diabetes Mellitus, Maturity-Onset//Diabetes Mellitus, Maturity Onset//Maturity-Onset Diabetes Mellitus//Maturity Onset Diabetes Mellitus//MODY//Diabetes Mellitus, Slow-Onset//Diabetes Mellitus, Slow Onset//Slow-Onset Diabetes Mellitus//Type 2 Diabetes Mellitus//Noninsulin-Dependent Diabetes Mellitus//Noninsulin Dependent Diabetes Mellitus//Maturity-Onset Diabetes//Diabetes, Maturity-Onset//Maturity Onset Diabetes//Type 2 Diabetes//Diabetes, Type 2//Diabetes Mellitus, Adult-Onset//Adult-Onset Diabetes Mellitus//Diabetes Mellitus, Adult Onset

 

Disease Association Statistics

Total Associated ncRNA Number:100   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
H19  (Score: 0.985791)
H19  (Score: 0.985791)
HIST1H2AG-6  (Score: 0.731059)
AIM1-3  (Score: 0.731059)
TP53COR1  (Score: 0.731059)
HIST1H2AG-6  (Score: 0.731059)
AIM1-3  (Score: 0.731059)
TP53COR1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:33007789
Disease Name:Diabetes Mellitus, Type 2
Sample:T2DM patients, INS-1 cell
Dysfunction Pattern:Interaction(miR-766-3p/NR3C2 )
Validated Method:CCK8//qRT-PCR//ELISA
Description:Serum expression of LINC-P21 was elevated in T2DM patients, which was correlated with fasting blood glucose levels and disease diagnosis. miR-766-3p could be directly inhibited by LINC-P21 in INS-1 cells and reverse the effects of LINC-P21 on β-cell function. Additionally, NR3C2 was determined as a target of miR-766-3p, which could be positively regulated by LINC-P21 and had same effects with LINC-P21 on INS-1 cell proliferation and insulin secretion.
Causality:Yes
Causal Description:The glucose-stimulated insulin secretion and the proliferation of INS-1 cells were enhanced by LINC-P21 knockdown, but the overexpression of LINC-P21 led to opposite effects.
Clinical-realted Application:Serum expression of LINC-P21 was elevated in T2DM patients, which was correlated with fasting blood glucose levels and disease diagnosis.