Entry Detail

General Information

Database ID: LDA0006702
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TTBK2
Full Name:tau tubulin kinase 2
Category:LncRNA
Species:Homo sapiens
Synonyms:SCA11|TTBK
Chromosome:15
Strand:-
Coordinate:
Start Site(bp):42738730End Site(bp):42921000
External Links:
Ensembl ID:ENSG00000128881
Ensembl Transcript ID:N/A
Entrez Gene:146057.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Glioma  (Score: 0.985791)
Glioma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qPCR//qRT-PCR//MTT//PCR//IF
Weak Evidence:

 

Reference

[1] PubMed ID:33116862
Disease Name:Glioma
Sample:glioma tissues and cells
Dysfunction Pattern:regulation[miR-1283 and CHD1]
Validated Method:qRT-PCR//Western Blot//PCR//IF
Description:circ-TTBK2 expression was increased in glioma tissues and cells.Down-regulation of circ-TTBK2 suppressed glioma development by regulating miR-1283 and CHD1, providing a new mechanism for understanding glioma pathogenesis.
Causality:Yes
Causal Description:circ-TTBK2 knockdown suppressed glioma cell proliferation, migration, invasion and glycolysis.Silence of circ-TTBK2 reduced xenograft tumor growth.
Clinical-realted Application:

[2] PubMed ID:32196629
Disease Name:Glioma
Sample:glioma tissues and cells
Dysfunction Pattern:regulation[miR-761/ITGB8 axis]
Validated Method:qPCR//MTT//PCR//IF
Description:Levels of circ-TTBK2 and ITGB8 were upregulated, whereas miR-761 level was low-expressed in glioma tissues and cells.Circ-TTBK2 regulated cell proliferation, invasion and ferroptosis via targeting ITGB8 by sponging miR-761 in glioma, providing a promising biomarker for the clinical therapy of human glioma.
Causality:Yes
Causal Description: Additionally, circ-TTBK2 knockdown or miR-761 increase could retard cell proliferation, invasion, and promote ferroptosis in glioma cells.
Clinical-realted Application: