Entry Detail

General Information

Database ID: LDA0006705
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TSPOAP1-AS1
Full Name:TSPOAP1, SUPT4H1 and RNF43 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:BZRAP1-AS1
Chromosome:17
Strand:+
Coordinate:
Start Site(bp):58325450End Site(bp):58353727
External Links:
Ensembl ID:ENSG00000265148
Ensembl Transcript ID:N/A
Entrez Gene:100506779.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:1090   
More Information
Causal ncRNA Number:936
Network:
Top Causal ncRNAs:
AFAP1-AS1  (Score: 1)
FEZF1-AS1  (Score: 1)
BCYRN1  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
AWPPH  (Score: 1)
DANCR  (Score: 1)
hsa_circ_0007385  (Score: 1)
hsa_circ_0074027  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Migration Assay//qRT-PCR//Colony Formation Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:36032951
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tumor tissues
Dysfunction Pattern:Expression(lower expressed)
Validated Method:In Vivo Experiment//Migration Assay//qRT-PCR//RNA-seq//Colony Formation Assay//Invasion Assay
Description: Compared with adjacent normal tissues, BZRAP1-AS1 showed lower expression in NSCLC tumor tissues.
Causality:Yes
Causal Description:Overexpression of BZRAP1-AS1 inhibited proliferation and migration of H1299 and HCC827 cells.
Clinical-realted Application:BZRAP1-AS1 was lower in T1 than T2-T4 patients, N1-N3 than N0 patients. Low level BZRAP1-AS1 was related to shorter overall survival time (OS) in lung adenocarcinoma (LUAD), and poor first progression time (FP) in LUAD and lung squamous cell carcinoma (LUSC) patients.