Entry Detail

General Information

Database ID: LDA0006706
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TSPOAP1-AS1
Full Name:TSPOAP1, SUPT4H1 and RNF43 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:BZRAP1-AS1
Chromosome:17
Strand:+
Coordinate:
Start Site(bp):58325450End Site(bp):58353727
External Links:
Ensembl ID:ENSG00000265148
Ensembl Transcript ID:N/A
Entrez Gene:100506779.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:7148D001172
Disease Name:rheumatoid arthritisArthritis, Rheumatoid
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Alias:Arthritis or polyarthritis, rheumatic//atrophic ArthritisArthritis, Rheumatoid//Rheumatoid Arthritis

 

Disease Association Statistics

Total Associated ncRNA Number:134   
More Information
Causal ncRNA Number:64
Network:
Top Causal ncRNAs:
GAS5  (Score: 1)
GAS5  (Score: 1)
NEAT1  (Score: 1)
NEAT1  (Score: 1)
LINC00638  (Score: 0.999893)
THRIL  (Score: 0.999893)
THRIL  (Score: 0.999893)
LINC00638  (Score: 0.999893)
ZFAS1  (Score: 0.985791)
MEG3  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:34766472
Disease Name:Arthritis, Rheumatoid
Sample:RA tissues
Dysfunction Pattern:Interaction(miR-1286/COL5A2 axis)
Validated Method:RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA
Description:BZRAP1-AS1 and COL5A2 were downregulated in RA tissues and RA-HFLS while miR-1286 was amplified. Our findings suggested that BZRAP1-AS1 sequestered miR-1286 and reshaped the COL5A2 expression, thereby suppressed RA-HFLS proliferation and inflammation, and triggered cell apoptosis, resulting in the attenuation of RA progression.
Causality:Yes
Causal Description:Overexpression of BZRAP1-AS1 reduced the RA-HFLS proliferation, IL-6, IL-1β, and TNF-α level and induced cell apoptosis while BZRAP1-AS1 silence produced an opposite effect.Overexpression of BZRAP1-AS1 reduced the miR-1286 expression which in turn increased the COL5A2 expression, thereby relieving the excessive proliferation and limited apoptosis in RA-HFLS.
Clinical-realted Application: