Entry Detail

General Information

Database ID: LDA0006738
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TPTEP1
Full Name:TPTE pseudogene 1
Category:LncRNA
Species:Homo sapiens
Synonyms:psiTPTE22
Chromosome:22
Strand:+
Coordinate:
Start Site(bp):16601911End Site(bp):16648830
External Links:
Ensembl ID:ENSG00000100181
Ensembl Transcript ID:N/A
Entrez Gene:387590.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:1090   
More Information
Causal ncRNA Number:936
Network:
Top Causal ncRNAs:
AFAP1-AS1  (Score: 1)
FEZF1-AS1  (Score: 1)
BCYRN1  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
AWPPH  (Score: 1)
DANCR  (Score: 1)
hsa_circ_0007385  (Score: 1)
hsa_circ_0074027  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32323798
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tissues
Dysfunction Pattern:interaction[sponges miR-328-5p]
Validated Method:qRT-PCR//Luciferase Report Assay//Western Blot
Description: In the present study, significant downregulation of TPTEP1 in tumors compared with normal tissues from patients with NSCLC was observed. Using a dual‑luciferase reporter assay and western blot analysis, it was further validated that TPTEP1 sponged miR‑328‑5p to upregulate Src kinase signaling inhibitor 1 (SRCIN1) in NSCLC cells.
Causality:Yes
Causal Description:Overexpression of TPTEP1 inhibited cell proliferation and induced apoptosis in NSCLC cells.
Clinical-realted Application:

[2] PubMed ID:34539985
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tissues
Dysfunction Pattern:Interaction(miR-761/LATS2 axis)
Validated Method:Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:Compared with the normal adjacent tissues, the expressions of TPTEP1 and LATS2 were significantly down-regulated in the NSCLC tissues, while the expression of miR-761 was significantly increased. LATS2 was identified as a direct target of miR-761. Overexpression of miR-761 could significantly block the inhibitory effects of TPTEP1 on NSCLC, which clearly indicated that miR-761 played an oncogenic role in promoting proliferation and metastasis, while its downstream factor, LATS2, exerted opposite effects.
Causality:Yes
Causal Description:Overexpression of TPTEP1 exhibited substantial antitumor effects on NSCLC, including inhibition of cell proliferation and metastasis, which was achieved by targeting miR-761 and subsequently attenuated the expression of LATS2.
Clinical-realted Application: