Entry Detail

General Information

Database ID: LDA0006749
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TRPM2-AS
Full Name:TRPM2 antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:TRPM2-AS1
Chromosome:21
Strand:-
Coordinate:
Start Site(bp):44414590End Site(bp):44425563
External Links:
Ensembl ID:ENSG00000230061
Ensembl Transcript ID:N/A
Entrez Gene:101928607.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:20   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Retinoblastoma  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Glioma  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3717
Disease Name:gastric adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A stomach carcinoma that derives_from epithelial cells of glandular origin.
Alias:adenocarcinoma of stomach//stomach adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:40   
More Information
Causal ncRNA Number:28
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
PMS2P2  (Score: 0.731059)
ITGB1-DT  (Score: 0.731059)
FOXCUT  (Score: 0.731059)
HAND2-AS1  (Score: 0.731059)
DIRC1  (Score: 0.731059)
RP1-163G9.1  (Score: 0.731059)
TM4SF1-AS1  (Score: 0.731059)
TRPM2-AS  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Migration Assay//Proliferation Assay//qRT-PCR//FISH//Cell Apoptosis Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34696681
Disease Name:gastric adenocarcinoma
Sample:tumor tissues and GAC cells
Dysfunction Pattern:Interaction(miR-138-5p/ PLAU)
Validated Method:Western Blot//Transfection//Migration Assay//Proliferation Assay//qRT-PCR//FISH//Cell Apoptosis Assay//RNA Network//Bioinformatics Analysis
Description:After performing quantitative Real-Time polymerase chain reaction or western blotting, we found that the levels of TRPM2-AS and Plasminogen Activator, Urokinase (PLAU) were upregulated in GAC, whereas the level of miR-138-5p was downregulated. Bioinformatic analysis and luciferase assay identified the interaction between TRPM2-AS, miR-138-5p, and PLAU.
Causality:Yes
Causal Description:Cell function experiments proved that silencing TRPM2-AS suppressed proliferation and migration and induced apoptosis in GAC cells. C
Clinical-realted Application: