Entry Detail

General Information

Database ID: LDA0006791
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TGFBR2
Full Name:transforming growth factor beta receptor 2
Category:LncRNA
Species:Homo sapiens
Synonyms:AAT3|FAA3|LDS1B|LDS2|LDS2B|MFS2|RIIC|TAAD2|TBR-ii|TBRII|TGFR-2|TGFbeta-RII|tbetaR-II
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):30606356End Site(bp):30694142
External Links:
Ensembl ID:ENSG00000163513
Ensembl Transcript ID:N/A
Entrez Gene:7048.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Nasopharyngeal carcinoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9261C538339
Disease Name:nasopharynx carcinomaNasopharyngeal carcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.A carcinoma that originates in the nasopharyngeal EPITHELIUM and includes 4 subtypes: keratinizing squamous cell, nonkeratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes. OMIM: 607107
Alias:Nasopharyngeal carcinoma//malignant Nasopharyngeal tumor//malignant neoplasm of nasopharynx//nasopharynx cancer

 

Disease Association Statistics

Total Associated ncRNA Number:260   
More Information
Causal ncRNA Number:244
Network:
Top Causal ncRNAs:
ZFAS1  (Score: 1)
ZFAS1  (Score: 1)
DANCR  (Score: 0.999893)
XIST  (Score: 0.999893)
XIST  (Score: 0.999893)
DANCR  (Score: 0.999893)
circZNF609  (Score: 0.985791)
hsa_circ_0008450  (Score: 0.985791)
PVT1  (Score: 0.985791)
circZNF609  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transwell Assay//Wound Healing Assay//Colony Formation Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//IHC//IF
Weak Evidence:

 

Reference

[1] PubMed ID:33160003
Disease Name:Nasopharyngeal carcinoma
Sample:NPC tissue samples
Dysfunction Pattern:Interaction(miR-107)
Validated Method:In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//FISH//IF//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay
Description:. Furthermore, the expression of circTGFBR2 was downregulated in NPC tissue samples, while circTGFBR2 overexpression correlated with favorable prognosis in NPC. Further analysis showed that circTGFBR2 sponged miR-107, leading to the upregulation of TGFBR2 expression and suppression of NPC progression.
Causality:Yes
Causal Description:Functionally, circTGFBR2 overexpression inhibited the proliferation and migration of NPC cells both in vitro and in vivo.
Clinical-realted Application:. Furthermore, the expression of circTGFBR2 was downregulated in NPC tissue samples, while circTGFBR2 overexpression correlated with favorable prognosis in NPC.