Entry Detail

General Information

Database ID: LDA0006795
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TFF1
Full Name:trefoil factor 1
Category:LncRNA
Species:Homo sapiens
Synonyms:BCEI|D21S21|HP1.A|HPS2|pNR-2|pS2
Chromosome:21
Strand:-
Coordinate:
Start Site(bp):42362282End Site(bp):42366535
External Links:
Ensembl ID:ENSG00000160182
Ensembl Transcript ID:N/A
Entrez Gene:7031.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1612D001943
Disease Name:breast cancerBreast Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A thoracic cancer that originates in the mammary gland.Tumors or cancer of the human BREAST.
Alias:breast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary tumor//primary breast cancerBreast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

 

Disease Association Statistics

Total Associated ncRNA Number:1186   
More Information
Causal ncRNA Number:766
Network:
Top Causal ncRNAs:
MILIP  (Score: 1)
GAS5  (Score: 1)
MILIP  (Score: 1)
H19  (Score: 1)
CDKN2B-AS1  (Score: 1)
DANCR  (Score: 1)
AFAP1-AS1  (Score: 1)
CDKN2B-AS1  (Score: 1)
NEAT1  (Score: 1)
circHIPK3  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qPCR//RIP//PCR//IP//IF
Weak Evidence:

 

Reference

[1] PubMed ID:31961997
Disease Name:Breast Neoplasms
Sample:breast cancer tissues
Dysfunction Pattern:regulation[miR-326/TFF1 signalling]
Validated Method:Western Blot//qPCR//RIP//PCR//Microarray//IP//IF
Description:Circ-TFF1 and TFF1 were both upregulated and positively associated with each other in breast cancer. Circ-TFF1 is a facilitator in breast cancer relying on TFF1 by absorbing miR-326, providing a novel promising target for BC treatment.
Causality:Yes
Causal Description: Knockdown of circ-TFF1 hindered breast cancer cell proliferation, migration, invasion and EMT in vitro and controlled tumour growth in vivo.
Clinical-realted Application: