Entry Detail

General Information

Database ID: LDA0006820
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TACR3-AS1
Full Name:N/A
Category:LncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:ENSG00000251577
Ensembl Transcript ID:N/A
Entrez Gene:N/A
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
laryngeal squamous cell carcinoma  (Score: 0.731059)
laryngeal squamous cell carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2876
Disease Name:laryngeal squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A laryngeal carcinoma that has_material_basis_in squamous cells.
Alias:Epidermoid carcinoma of the Larynx//squamous cell carcinoma of larynx

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
CDKN2B-AS1  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
LINC01638  (Score: 0.731059)
AC023794.4-201  (Score: 0.731059)
hsa_circ_0006232  (Score: 0.731059)
hsa_circ_0067934  (Score: 0.731059)
TACR3-AS1  (Score: 0.731059)
LINC01638  (Score: 0.731059)
AC023794.4-201  (Score: 0.731059)
hsa_circ_0006232  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Wound Healing Assay//qRT-PCR//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33893613
Disease Name:laryngeal squamous cell carcinoma
Sample:LSCC cells
Dysfunction Pattern:Regulation
Validated Method:Western Blot//Transfection//Wound Healing Assay//qRT-PCR//EdU Staining//Transwell Assay
Description:These results suggested that RP11-297P16.3 may inhibit the migration and invasion of LSCC cells by regulating the epithelial-mesenchymal transition process, suggesting that RP11-297P16.3 is a potential new target for treating LSCC.
Causality:Yes
Causal Description:Moreover, knockdown of RP11-297P16.3 significantly inhibited the migration and invasion of LSCC cells but had no effect on cell proliferation. The protein expression of N-cadherin and vimentin was notably decreased after RP11-297P16.3 knockdown; whereas, the protein expression of cadherin was significantly increased
Clinical-realted Application: