Entry Detail

General Information

Database ID: LDA0006829
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TCFL5
Full Name:transcription factor like 5
Category:LncRNA
Species:Homo sapiens
Synonyms:CHA|E2BP-1|Figlb|SOSF1|bHLHe82
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):62841005End Site(bp):62861822
External Links:
Ensembl ID:ENSG00000101190
Ensembl Transcript ID:N/A
Entrez Gene:10732.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Esophageal Neoplasms  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5041D004938
Disease Name:esophageal cancerEsophageal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the esophagus.Tumors or cancer of the ESOPHAGUS.
Alias:Ca lower third oesophagus//Ca middle third oesophagus//esophagus cancer//malignant neoplasm of distal third of esophagus//malignant neoplasm of lower third of oesophagus//malignant neoplasm of middle third of oesophagus//malignant neoplasm of proximal third of esophagus//malignant neoplasm of upper third esophagus//malignant tumor of Distal Third of esophagus//malignant tumor of Proximal Third of esophagus//malignant tumor of abdominal esophagus//malignant tumor of the middle Third of the esophagusEsophageal Neoplasms//Esophageal Neoplasm//Neoplasm, Esophageal//Esophagus Neoplasm//Esophagus Neoplasms//Neoplasm, Esophagus//Neoplasms, Esophagus//Neoplasms, Esophageal//Cancer of Esophagus//Cancer of the Esophagus//Esophagus Cancer//Cancer, Esophagus//Cancers, Esophagus//Esophagus Cancers//Esophageal Cancer//Cancer, Esophageal//Cancers, Esophageal//Esophageal Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:202   
More Information
Causal ncRNA Number:148
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.999893)
UCA1  (Score: 0.999893)
ADAMTS9-AS2  (Score: 0.985791)
ADAMTS9-AS2  (Score: 0.985791)
circPRKCI  (Score: 0.731059)
hsa_circ_0006168  (Score: 0.731059)
hsa_circ_0008717  (Score: 0.731059)
hsa_circ_0023397  (Score: 0.731059)
LINC01234  (Score: 0.731059)
LINC00963  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Tunel
Weak Evidence:

 

Reference

[1] PubMed ID:35646112
Disease Name:Esophageal Neoplasms
Sample:esophageal cancer tissues
Dysfunction Pattern:Interaction(miR-543-FMNL2 Axis)
Validated Method:qRT-PCR//Tunel
Description:156 upregulated circRNAs and 91 downregulated circRNAs in esophageal cancer tissues were identified, and the expression of circRNA TCFL5 showed the most significant upregulation. Overexpression of circRNA TCFL5 promotes proliferation, invasion, and migration of Eca109 and KYSE150 and promotes tumor growth in vivo. circRNA TCFL5 served as a sponge of miR-543, and FMNL2 was a downstream target gene of miR-543. circRNA TCFL5 promotes cell proliferation, migration, and invasion of Eca109 and KYSE150 by modulating the miR-543/FMNL2 axis. Macrophage M2 polarization promoted proliferation, invasion, and migration of Eca109 and KYSE150 cells, and circRNA TCFL5 mediated macrophage M2 polarization by regulating the FMNL2/miR-543 axis.
Causality:Yes
Causal Description:Overexpression of circRNA TCFL5 promotes proliferation, invasion, and migration of Eca109 and KYSE150 and promotes tumor growth in vivo.
Clinical-realted Application: