Entry Detail

General Information

Database ID: LDA0006834
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TCLlnc1
Full Name:ferritin heavy chain 1 pseudogene 24
Category:LncRNA
Species:Homo sapiens
Synonyms:FTHL24|TCLlnc1
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):139546278End Site(bp):139546888
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:100462797.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Lymphoma, T-Cell, Peripheral  (Score: 0.731059)
Lymphoma, T-Cell, Peripheral  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D016411
Disease Name:Lymphoma, T-Cell, Peripheral
Category:MeSH
Type:Neoplasms
Define:A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.
Alias:Lymphoma, T-Cell, Peripheral//Peripheral T-Cell Lymphoma//Lymphoma, Peripheral T-Cell//Lymphomas, Peripheral T-Cell//Peripheral T Cell Lymphoma//Peripheral T-Cell Lymphomas//T-Cell Lymphomas, Peripheral//T-Cell Lymphoma, Peripheral//T Cell Lymphoma, Peripheral//Lymphoma, T Cell, Peripheral

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
TCLlnc1  (Score: 0.731059)
TCLlnc1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Co-IP//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33767152
Disease Name:Lymphoma, T-Cell, Peripheral
Sample:main subtypes of PTCL
Dysfunction Pattern:Interaction(HNRNPD/YBX1 complex )
Validated Method:In Vivo Experiment//Western Blot//Co-IP//qRT-PCR//FISH//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay
Description:In this research, a novel lncRNA (ENST00000503502) was identified overexpressed in the main subtypes of PTCL, and designated as T cell lymphoma-associated lncRNA1 (TCLlnc1). As the mechanism of action, TCLlnc1 directly interacted with transcription activator heterogeneous nuclear ribonucleoprotein D (HNRNPD) and Y-box binding protein-1 (YBX1) by acting as a modular scaffold.
Causality:Yes
Causal Description:Both in vitro and in vivo, overexpression of TCLlnc1 promoted T-lymphoma cell proliferation and migration, both of which were counteracted by the knockdown of TCLlnc1 using small interfering RNAs.
Clinical-realted Application:Serum TCLlnc1 was associated with extranodal involvement, high-risk International Prognostic Index, and poor prognosis of the patients.