Entry Detail

General Information

Database ID: LDA0006849
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:THAP9-AS1
Full Name:THAP9 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:4
Strand:-
Coordinate:
Start Site(bp):82893452End Site(bp):82900916
External Links:
Ensembl ID:ENSG00000251022
Ensembl Transcript ID:N/A
Entrez Gene:100499177.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3498
Disease Name:pancreatic ductal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic adenocarcinoma that derives_from pancreatic duct cells.
Alias:ductal adenocarcinoma of the pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:110
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
circMYOF  (Score: 0.731059)
circBFAR  (Score: 0.731059)
hsa_circ_000684  (Score: 0.731059)
circSLIT2  (Score: 0.731059)
hsa_circ_0005105  (Score: 0.731059)
circEYA3  (Score: 0.731059)
circNEIL3  (Score: 0.731059)
hsa_circ_0047744  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RIP//qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31831555
Disease Name:pancreatic ductal adenocarcinoma
Sample:PDAC tissues
Dysfunction Pattern:Regulation[THAP9-AS1/YAP axis ]
Validated Method:RIP//qRT-PCR
Description:We demonstrated that lncRNA THAP9-AS1 is overexpressed in PDAC in multiple patient sample sets, which is significantly associated with poor outcome of patients with PDAC. Our findings indicate that THAP9-AS1 plays an important role in PDAC growth via enhancing YAP signaling, which in turn also modulates THAP9-AS1 transcription. THAP9-AS1/YAP axis may serve as a potential biomarker and therapeutic target for PDAC treatment.
Causality:Yes
Causal Description:THAP9-AS1 promotes PDAC cells growth both in vitro and in vivo.
Clinical-realted Application: