Entry Detail

General Information

Database ID: LDA0006864
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TM4SF1-AS1
Full Name:TM4SF1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):149377778End Site(bp):149386583
External Links:
Ensembl ID:ENSG00000240541
Ensembl Transcript ID:N/A
Entrez Gene:100874091.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
gastric adenocarcinoma  (Score: 0.731059)
gastric adenocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3717
Disease Name:gastric adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A stomach carcinoma that derives_from epithelial cells of glandular origin.
Alias:adenocarcinoma of stomach//stomach adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:40   
More Information
Causal ncRNA Number:28
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
PMS2P2  (Score: 0.731059)
ITGB1-DT  (Score: 0.731059)
FOXCUT  (Score: 0.731059)
HAND2-AS1  (Score: 0.731059)
DIRC1  (Score: 0.731059)
RP1-163G9.1  (Score: 0.731059)
TM4SF1-AS1  (Score: 0.731059)
TRPM2-AS  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transfection//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35311149
Disease Name:gastric adenocarcinoma
Sample:CD8+ T cells
Dysfunction Pattern:Regulation
Validated Method:Transfection//qRT-PCR//Survival Analysis//Luciferase Report Assay//RNA-seq//ChIP-seq
Description:We found that the expression of SE-associated lncRNA TM4SF1-AS1 was negatively correlated with the proportion of CD8+ T cells present in STAD. TM4SF1-AS1 suppresses T cell-mediated immune killing function and predicts immune response to anti-PD1 therapy.
Causality:Yes
Causal Description:TM4SF1-AS1 suppresses T cell-mediated immune killing function and predicts immune response to anti-PD1 therapy.
Clinical-realted Application: