| [1] PubMed ID: | 34733920 |
| Disease Name: | Arthritis, Rheumatoid |
| Sample: | synovial tissue (ST) specimens from RA patients with active disease (n=10, 7 females and 3 males; age range: 46–61 years) and osteoarthritis patients (n=5, 3 females and 2 males; age range: 54–66 years) |
| Dysfunction Pattern: | Expression [highly expressed] |
| Validated Method: | Transfection//EdU Staining//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Invasion Assay |
| Description: | A significant decrease in THRIL expression was found in RA FLSs compared with cells from healthy control (HC)patients. THRIL is mainly localized in the nucleus. |
| Causality: | Yes |
| Causal Description: | Knockdown of THRIL increased the proliferation, migration, and invasion of RA FLSs. In contrast, THRIL overexpression had the opposite effect. |
| Clinical-realted Application: | |
| [2] PubMed ID: | 31346885 |
| Disease Name: | Arthritis, Rheumatoid |
| Sample: | blood |
| Dysfunction Pattern: | Expression[highly expressed] |
| Validated Method: | qRT-PCR |
| Description: | The results indicate that T cells of RA patients display increased levels of GAS5 (3.31-fold, p = 0.007), RMRP (2.43-fold, p = 0.02), and THRIL (2.14-fold, p = 0.03) lncRNAs compared with those of controls. |
| Causality: | No |
| Causal Description: | |
| Clinical-realted Application: | |
| [3] PubMed ID: | 32232711 |
| Disease Name: | Arthritis, Rheumatoid |
| Sample: | serum |
| Dysfunction Pattern: | regulation[PI3K/AKT Signals] |
| Validated Method: | qRT-PCR//ELISA//MTT |
| Description: | The qRT-PCR analysis was employed for evaluating the levels of THRIL in the serum.The present study revealed that THRIL could regulate cell growth and inflammatory response of FLSs by activating the PI3K/AKT signaling pathway, subsequently playing important roles in promoting the occurrence and development of RA. |
| Causality: | No |
| Causal Description: | |
| Clinical-realted Application: | |
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