Entry Detail

General Information

Database ID: LDA0006909
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TINCR
Full Name:TINCR ubiquitin domain containing
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00036|NCRNA00036|PLAC2|TUBL|onco-lncRNA-16
Chromosome:19
Strand:-
Coordinate:
Start Site(bp):5558167End Site(bp):5567953
External Links:
Ensembl ID:ENSG00000223573
Ensembl Transcript ID:N/A
Entrez Gene:257000.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:40   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Urinary Bladder Neoplasms  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Breast Neoplasms  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Melanoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D001743
Disease Name:Urinary Bladder
Category:MeSH
Type:Urogenital System
Define:A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.
Alias:Urinary Bladder//Bladder, Urinary//Bladder//Bladder Detrusor Muscle//Bladder Detrusor Muscles//Detrusor Muscle, Bladder//Detrusor Muscles, Bladder//Detrusor Urinae

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
TINCR  (Score: 0.731059)
TINCR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Wound Healing Assay//ELISA//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32622721
Disease Name:Urinary Bladder
Sample:cancerous tissues
Dysfunction Pattern:interaction[Hsa-miR-125b ]
Validated Method:qRT-PCR//Wound Healing Assay//ELISA//Luciferase Report Assay
Description:The expression levels of TINCR were higher in cancerous tissues than that in paired noncancerous tissues of UCB. Hsa-miR-125b is a target for TINCR in UCB.
Causality:Yes
Causal Description:Depletion of TINCR retarded proliferation, decreased motility, increased apoptosis in UCB cells, and markedly reduced tumor growth in xenograft nude mice.
Clinical-realted Application:Higher expression levels of TINCR were positively associated with high-grade, invasive, and recurring tumors.