Entry Detail

General Information

Database ID: LDA0006920
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TINCR
Full Name:TINCR ubiquitin domain containing
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00036|NCRNA00036|PLAC2|TUBL|onco-lncRNA-16
Chromosome:19
Strand:-
Coordinate:
Start Site(bp):5558167End Site(bp):5567953
External Links:
Ensembl ID:ENSG00000223573
Ensembl Transcript ID:N/A
Entrez Gene:257000.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:40   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Urinary Bladder Neoplasms  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Breast Neoplasms  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Melanoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11612D011085
Disease Name:polycystic ovary syndromePolycystic Ovary Syndrome
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight.A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
Alias:Multicystic ovaries//PCOS//Polycystic Ovarian disease//Polycystic ovaries//Stein-Leventhal synd.//Stein-Leventhal syndrome//polycystic ovaryPolycystic Ovary Syndrome//Ovary Syndrome, Polycystic//Syndrome, Polycystic Ovary//Stein-Leventhal Syndrome//Stein Leventhal Syndrome//Syndrome, Stein-Leventhal//Sclerocystic Ovarian Degeneration//Ovarian Degeneration, Sclerocystic//Sclerocystic Ovary Syndrome//Polycystic Ovarian Syndrome//Ovarian Syndrome, Polycystic//Polycystic Ovary Syndrome 1//Sclerocystic Ovaries//Ovary, Sclerocystic//Sclerocystic Ovary

 

Disease Association Statistics

Total Associated ncRNA Number:126   
More Information
Causal ncRNA Number:34
Network:
Top Causal ncRNAs:
hsa_circ_0043532  (Score: 0.985791)
hsa_circ_0043532  (Score: 0.985791)
MALAT1  (Score: 0.731059)
BANCR  (Score: 0.731059)
LINC00477  (Score: 0.731059)
lncROR  (Score: 0.731059)
H19  (Score: 0.731059)
lnc-CCNL1-3:1  (Score: 0.731059)
GAS5  (Score: 0.731059)
lnc-MAP3K13-7:1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qPCR//Luciferase Report Assay//Cell Apoptosis Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34967266
Disease Name:Polycystic Ovary Syndrome
Sample:PCOS patient and cells
Dysfunction Pattern:Interaction(miR-19a/TNF-α)
Validated Method:Western Blot//Transfection//qPCR//Luciferase Report Assay//Cell Apoptosis Assay
Description:The results showed that PLAC2 was upregulated in PCOS. PLAC2 and miR-19a showed a direct interaction, while overexpression of PLAC2 and miR-19a did not affect the expression of each other in KGN cells. Instead, overexpression of PLAC2 led to upregulated TNF-α, which is a target of miR-19a. Therefore, PLAC2 may regulate miR-19a/TNF-α to participate in PCOS.
Causality:Yes
Causal Description:Cell apoptosis analysis showed that PLAC2 and TNF-α promoted the apoptosis of KGN cells. Overexpression of miR-19a played an opposite role. In addition, the overexpression of PLAC2 reduced the effects of overexpression of miR-19a.
Clinical-realted Application: