Entry Detail

General Information

Database ID: LDA0007007
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIR194-2HG
Full Name:MIR194-2 host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):64888458End Site(bp):64893449
External Links:
Ensembl ID:ENSG00000229719
Ensembl Transcript ID:N/A
Entrez Gene:105369343.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Liver Neoplasms  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3571D008113
Disease Name:liver cancerLiver Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A hepatobiliary system cancer that is located_in the liver.Tumors or cancer of the LIVER.
Alias:Ca liver - primary//Resectable malignant neoplasm of Liver//hepatic cancer//hepatic neoplasm//malignant hepato-biliary neoplasm//malignant neoplasm of liver//malignant neoplasm of liver, not specified as primary or secondary//malignant neoplasm of liver, primary//malignant tumor of liver//neoplasm of liver//non-resectable primary hepatic malignant neoplasm//primary liver cancer//primary malignant neoplasm of liver//resectable malignant neoplasm of the liverLiver Neoplasms//Neoplasms, Hepatic//Neoplasms, Liver//Liver Neoplasm//Neoplasm, Liver//Hepatic Neoplasms//Hepatic Neoplasm//Neoplasm, Hepatic//Cancer of Liver//Hepatocellular Cancer//Cancers, Hepatocellular//Hepatocellular Cancers//Hepatic Cancer//Cancer, Hepatic//Cancers, Hepatic//Hepatic Cancers//Liver Cancer//Cancer, Liver//Cancers, Liver//Liver Cancers//Cancer of the Liver//Cancer, Hepatocellular

 

Disease Association Statistics

Total Associated ncRNA Number:162   
More Information
Causal ncRNA Number:138
Network:
Top Causal ncRNAs:
SNHG1  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
CEBPA-DT  (Score: 0.985791)
CEBPA-DT  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
BCAR4  (Score: 0.985791)
BCAR4  (Score: 0.985791)
SNHG1  (Score: 0.985791)
HULC  (Score: 0.985791)
GAS5  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33116574
Disease Name:Liver Neoplasms
Sample:liver cancer tissues and cell lines
Dysfunction Pattern:regulation[miR-1207-5p/TCF19/Wnt/β-Catenin Signaling]
Validated Method:Western Blot//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay
Description:MIR194-2HG was upregulated in liver cancer tissues and cell lines. MIR194-2HG acts in an oncogenic role and activates the Wnt/β-catenin signaling pathway via a miR-1207-5p/TCF19 axis-mediated mechanism, which provides a novel avenue for diagnostic or therapeutic interventions in liver cancer.
Causality:Yes
Causal Description:MIR194-2HG promoted the proliferation, migration, and invasion of HepG2 and Huh7 cells by acting as a ceRNA mechanism for the miR-1207-5p/TCF19 axis to activate the Wnt/β-catenin signaling pathway.
Clinical-realted Application:Liver cancer patients with higher expression of MIR194-2HG revealed poor overall survival compared with those who had lower expression of MIR194-2HG.