Entry Detail

General Information

Database ID: LDA0007026
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIR205HG
Full Name:MIR205 host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:LEADR|LINC00510|NPC-A-5
Chromosome:1
Strand:+
Coordinate:
Start Site(bp):209428820End Site(bp):209432549
External Links:
Ensembl ID:ENSG00000230937
Ensembl Transcript ID:N/A
Entrez Gene:642587.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.985791)
lung squamous cell carcinoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
lung squamous cell carcinoma  (Score: 0.985791)
Myocardial Reperfusion Injury  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Melanoma  (Score: 0.731059)
esophageal carcinoma  (Score: 0.731059)
Hepatoblastoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3907
Disease Name:lung squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A non-small cell lung carcinoma that has_material_basis_in the squamous cell.
Alias:Epidermoid cell carcinoma of the lung

 

Disease Association Statistics

Total Associated ncRNA Number:92   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
PITPNA-AS1  (Score: 0.985791)
PITPNA-AS1  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
LINC00519  (Score: 0.731059)
circTP63  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
ATB  (Score: 0.731059)
LINC00668  (Score: 0.731059)
MAGI2-AS3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Flow Cytometry//qRT-PCR//RIP//CCK8//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32513149
Disease Name:lung squamous cell carcinoma
Sample:LUSC tissues and cell lines
Dysfunction Pattern:regulation[miR-299-3p/MAP3K2 axis]
Validated Method:Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:The expression levels of MIR205HG in LUSC tissues and cell lines were obviously up-regulated. MIR205HG acts as a competing endogenous RNA (ceRNA) to expedite cell proliferation and progression via targeting miR-299-3p in LUSC.
Causality:Yes
Causal Description:Down-regulation of MIR205HG expression remarkably reduced cell proliferation, migration and epithelial-to-mesenchymal transition (EMT) progression, whereas promoted cell apoptosis.
Clinical-realted Application:

[2] PubMed ID:32188965
Disease Name:lung squamous cell carcinoma
Sample:LUSC samples
Dysfunction Pattern:Expression[highly expressed]
Validated Method:CCK8//Colony Formation Assay//Flow Cytometry//Western Blot
Description:Our results showed that CTD-2562J17.6 and FENDRR were significantly downregulated while MIR205HG, LNC_000378, RP11-116G8.5, RP3-523K23.2, and RP5-968D22.1 were significantly upregulated in all five LUSC samples. Importantly, MIR205HG was upregulated in LUSC clinical samples as well as in LUSC cell lines.
Causality:No
Causal Description:
Clinical-realted Application: