Entry Detail

General Information

Database ID: LDA0007028
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIR205HG
Full Name:MIR205 host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:LEADR|LINC00510|NPC-A-5
Chromosome:1
Strand:+
Coordinate:
Start Site(bp):209428820End Site(bp):209432549
External Links:
Ensembl ID:ENSG00000230937
Ensembl Transcript ID:N/A
Entrez Gene:642587.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.985791)
lung squamous cell carcinoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
lung squamous cell carcinoma  (Score: 0.985791)
Myocardial Reperfusion Injury  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Melanoma  (Score: 0.731059)
esophageal carcinoma  (Score: 0.731059)
Hepatoblastoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:687D018197
Disease Name:hepatoblastomaHepatoblastoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)
Alias:Hepatoblastoma//Hepatoblastomas

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
ZFAS1  (Score: 0.731059)
LINC00205  (Score: 0.731059)
GAS5  (Score: 0.731059)
LUCAT1  (Score: 0.731059)
LINC01023  (Score: 0.731059)
circHMGCS1  (Score: 0.731059)
circSETD3  (Score: 0.731059)
hsa_circ_0000594  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
MIR210HG  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34996511
Disease Name:Hepatoblastoma
Sample:HB tissues and cells
Dysfunction Pattern:Interaction(miR-514a-5p/MAPK/ PI3K/AKT)
Validated Method:RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Description:MIR205HG was significantly overexpressed in HB. Furthermore, MIR205HG competitively bound to microRNA-514a-5p (miR-514a-5p) and targeted mitogen-activated protein kinase 9 (MAPK9) to stimulate mitogen activated protein kinase (MAPK) signaling pathway. Besides, MIR205HG also served as a sponge for microRNA-205-5p (miR-205-5p) to activate the PI3K/AKT signaling pathway.
Causality:Yes
Causal Description:Moreover, MIR205HG inhibition suppressed the proliferative, migratory and invasive capacities of HB cells.
Clinical-realted Application: