Entry Detail

General Information

Database ID: LDA0007125
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:289D004715
Disease Name:endometriosisEndometriosis
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
Alias:Endometriosis//Endometrioses//Endometrioma//Endometriomas

 

Disease Association Statistics

Total Associated ncRNA Number:46   
More Information
Causal ncRNA Number:42
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.999893)
AFAP1-AS1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
AFAP1-AS1  (Score: 0.999893)
HOTAIR  (Score: 0.985791)
HOTAIR  (Score: 0.985791)
circATRNL1  (Score: 0.985791)
circATRNL1  (Score: 0.985791)
DHRS4  (Score: 0.731059)
CCDC144NL-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Flow Cytometry//MTT//H&E Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35094286
Disease Name:Endometriosis
Sample:EM tissues and cells
Dysfunction Pattern:Interaction(miR-124-3p)
Validated Method:Western Blot//Flow Cytometry//MTT//H&E Staining//Transwell Assay
Description:MiR-124-3p was identified as a target of NEAT1, and could be negatively regulated by NEAT1 in EC-ESCs. The expression level of NEAT1 was evidently increased, whereas that of miR-124-3p was decreased, in the EM in vivo model, EM tissues and EC-ESCs from patients with EM. The loss-of-function assays further established that silencing of NEAT1 could inhibit EC-ESC proliferation, migration, and invasion, but it led to the promotion of apoptosis via targeting miR-124-3p.
Causality:Yes
Causal Description:The loss-of-function assays further established that silencing of NEAT1 could inhibit EC-ESC proliferation, migration, and invasion, but it led to the promotion of apoptosis via targeting miR-124-3p.
Clinical-realted Application: