Entry Detail


General Information

Database ID: LDA0007167
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIR503HG
Full Name:MIR503 host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:H19X|MIR503HG2
Chromosome:X
Strand:-
Coordinate:
Start Site(bp):134543377End Site(bp):134546630
External Links:
Ensembl ID:ENSG00000223749
Ensembl Transcript ID:ENSG00000223749
Entrez Gene:84848.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:24   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Pre-Eclampsia  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10591D011225
Disease Name:pre-eclampsiaPre-Eclampsia
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
Alias:gestational hypertension//hypertension induced by pregnancy//pre-eclamptic toxaemia//preeclampsia//preeclampsia/eclampsia//pregnancy associated hypertension//pregnancy toxemia//proteinuric hypertension of pregnancy//toxaemia of pregnancyPre-Eclampsia//Pre Eclampsia//Preeclampsia//Pregnancy Toxemias//Pregnancy Toxemia//Toxemia, Pregnancy//Edema-Proteinuria-Hypertension Gestosis//Edema Proteinuria Hypertension Gestosis//Gestosis, Edema-Proteinuria-Hypertension//Hypertension-Edema-Proteinuria Gestosis//Gestosis, Hypertension-Edema-Proteinuria//Hypertension Edema Proteinuria Gestosis//Toxemia Of Pregnancy//Of Pregnancies, Toxemia//Of Pregnancy, Toxemia//Pregnancies, Toxemia Of//Pregnancy, Toxemia Of//Toxemia Of Pregnancies//EPH Complex//EPH Toxemias//EPH Toxemia//Toxemia, EPH//Toxemias, EPH//EPH Gestosis//Gestosis, EPH//Toxemias, Pregnancy//Preeclampsia Eclampsia 1//1, Preeclampsia Eclampsia//1s, Preeclampsia Eclampsia//Eclampsia 1, Preeclampsia//Eclampsia 1s, Preeclampsia//Preeclampsia Eclampsia 1s//Proteinuria-Edema-Hypertension Gestosis//Gestosis, Proteinuria-Edema-Hypertension//Proteinuria Edema Hypertension Gestosis

 

Disease Association Statistics

Total Associated ncRNA Number:42   
More Information
Causal ncRNA Number:36
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.985791)
HOTAIR  (Score: 0.985791)
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
DLX6-AS1  (Score: 0.731059)
UCA1  (Score: 0.731059)
SNHG14  (Score: 0.731059)
APOA1-AS  (Score: 0.731059)
uc.187  (Score: 0.731059)
DANCR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31467616
Disease Name:Pre-Eclampsia
Sample:placental tissues
Dysfunction Pattern:Regulation[ NF-κB signaling pathway]
Validated Method:Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Transwell Assay
Description:The highly expressed MIR503HG was detected in PE placental tissues compared to normal placental tissues.Western blot assay results showed that MIR503HG overexpression suppressed the matrix metalloproteinase-2/-9 and the snail protein expression and increased the E-cadherin expression in trophoblast cells. In addition, MIR503HG overexpression suppressed the NF-κB signaling pathway by inhibiting the phosphorylation of IκBα and the nuclear translocation of NF-κB signaling subunit p65. On the other hand, MIR503HG knockdown played an opposite role in these protein expression levels.
Causality:Yes
Causal Description:MIR503HG overexpression suppressed cell proliferation, invasion, and migration of HTR-8/SVneo and JEG3 cells, while knockdown of MIR503HG increased trophoblast cell proliferation, invasion, and migration.
Clinical-realted Application: