Entry Detail

General Information

Database ID: LDA0007170
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4481D065631
Disease Name:allergic rhinitisRhinitis, Allergic
Category:Disease OntologyMeSH
Type:Respiratory Tract Diseases
Define:A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.An inflammation of the NASAL MUCOSA triggered by ALLERGENS.
Alias:Non-seasonal allergic rhinitis//Perenial allergic rhinitis//atopic rhinitis//hay fever//pollenosis//seasonal allergic rhinitisRhinitis, Allergic//Allergic Rhinitides//Rhinitides, Allergic//Allergic Rhinitis

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
CDKN2B-AS1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
HCP5  (Score: 0.731059)
FR215775  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0067835  (Score: 0.731059)
HCP5  (Score: 0.731059)
FR215775  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Tunel//qRT-PCR//Luciferase Report Assay//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:34672863
Disease Name:Rhinitis, Allergic
Sample:AR and IL-13-treated HNECs
Dysfunction Pattern:Interaction(miR-511/NR4A2 axis)
Validated Method:Western Blot//Transfection//Tunel//qRT-PCR//Luciferase Report Assay//ELISA
Description:In this study, we found that the NEAT1 level was highly expressed in AR and IL-13-treated HNECs. In conclusion, our data revealed that exosomal NEAT1 contributed to the pathogenesis of AR through the miR-511/NR4A2 axis. These findings might offer novel strategies for the prevention and treatment of AR.
Causality:Yes
Causal Description: NEAT1 interference significantly suppressed levels of GM-CSF, eotaxin-1, and MUC5AC and apoptosis rate, but promoted the viability of IL-13-treated human nasal epithelial cells (HNECs). Moreover, exosomes containing NEAT1 induced inflammatory cytokine production and apoptosis, while NEAT1 depletion abrogated these effects.
Clinical-realted Application:

[2] PubMed ID:35064698
Disease Name:Rhinitis, Allergic
Sample:pediatric AR patients, DCs and HCs
Dysfunction Pattern:Interaction(microRNA-125a)
Validated Method:qRT-PCR
Description:Lnc-NEAT1 was overexpressed, while miR-125a downregulated in pediatric AR patients compared to DCs and HCs (all p < 0.001). Moreover, lnc-NEAT1 expression negatively correlated with miR-125a expression in pediatric AR patients (p = 0.002), but not in DCs (p = 0.226) or HCs (p = 0.237). Additionally, lnc-NEAT1 expression positively, while miR-125a expression negatively correlated with Th2 cells and IL-10 (all p < 0.05), but they were not correlated with Th1 cells or IFN-γ in pediatric AR patients.
Causality:No
Causal Description:
Clinical-realted Application: Furthermore, in pediatric AR patients, lnc-NEAT1 expression positively associated with TNSS (p < 0.001), sneezing score (p = 0.006), and congestion score (p = 0.008); miR-125a expression was negatively related to TNSS (p < 0.001), itching score (p = 0.040), and sneezing score (p = 0.005).