Entry Detail

General Information

Database ID: LDA0007210
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEF
Full Name:S100 calcium binding protein B
Category:LncRNA
Species:Homo sapiens
Synonyms:NEF|S100|S100-B|S100beta
Chromosome:21
Strand:-
Coordinate:
Start Site(bp):46598604End Site(bp):46605082
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:6285.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:20   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Thyroid Cancer, Papillary  (Score: 0.731059)
Small Cell Lung Carcinoma  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
cervical squamous cell carcinoma  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//ELISA//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31258706
Disease Name:Glioma
Sample:glioma Tissue
Dysfunction Pattern:Interaction[miR-548g,YBX4]
Validated Method:qRT-PCR//ELISA//Western Blot
Description:It was determined that NEF expression was Expression[down-expression]regulated in tumor tissues compared with adjacent heathy tissues. Blood NEF levels were negatively correlated with blood transforming growth factor (TGF)-β1 levels in patients with distant tumor metastasis, but not in patients with non-metastatic glioma and healthy controls.
Causality:Yes
Causal Description:NEF overexpression inhibited cancer cell migration and invasion. In addition, NEF overexpression Expression[down-expression]regulated TGF-β1 expression.
Clinical-realted Application: