Entry Detail

General Information

Database ID: LDA0007238
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIR99AHG
Full Name:mir-99a-let-7c cluster host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:C21orf34|C21orf35|DILA1|LINC00478|MONC
Chromosome:21
Strand:+
Coordinate:
Start Site(bp):16070488End Site(bp):16631727
External Links:
Ensembl ID:ENSG00000215386
Ensembl Transcript ID:N/A
Entrez Gene:388815.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Mycobacterium tuberculosis  (Score: 0.731059)
Pulmonary Fibrosis  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Mycobacterium tuberculosis  (Score: 0.731059)
Pulmonary Fibrosis  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3770D011658
Disease Name:pulmonary fibrosisPulmonary Fibrosis
Category:Disease OntologyMeSH
Type:Respiratory Tract Diseases
Define:An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation.A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Alias:Fibrosis of lungPulmonary Fibrosis//Fibrosis, Pulmonary//Pulmonary Fibroses//Fibroses, Pulmonary//Alveolitis, Fibrosing//Alveolitides, Fibrosing//Fibrosing Alveolitides//Fibrosing Alveolitis//Idiopathic Diffuse Interstitial Pulmonary Fibrosis

 

Disease Association Statistics

Total Associated ncRNA Number:64   
More Information
Causal ncRNA Number:16
Network:
Top Causal ncRNAs:
H19  (Score: 0.731059)
DACH1  (Score: 0.731059)
Rmrp  (Score: 0.731059)
circANKRD42  (Score: 0.731059)
Zfas1  (Score: 0.731059)
hsa_circ_0026344  (Score: 0.731059)
hsa_circ_0044226  (Score: 0.731059)
MIR99AHG  (Score: 0.731059)
H19  (Score: 0.731059)
DACH1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Co-IP//Migration Assay//FISH//qRT-PCR//Luciferase Report Assay//Invasion Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:36138468
Disease Name:Pulmonary Fibrosis
Sample:LUAD tissues and cell lines
Dysfunction Pattern:Interaction(miR-136-5p/USP4/ACE2 axis)
Validated Method:Western Blot//Transfection//Co-IP//Migration Assay//FISH//qRT-PCR//Luciferase Report Assay//Invasion Assay//IF
Description:LncRNA MIR99AHG expression level was downregulated in LUAD tissues and cell lines. Functional analysis showed that MIR99AHG is associated with the LUAD malignant phenotype in vitro and in vivo. Further mechanistic studies showed that, MIR99AHG functions as a competitive endogenous RNA (ceRNA) to antagonize miR-136-5p-mediated ubiquitin specific protease 4 (USP4) degradation, thereby unregulated the expression of angiotensin-converting enzyme 2 (ACE2), a downstream target gene of USP4, which in turn affected alveolar type II epithelial cell fibrosis and epithelial-mesenchymal transition (EMT).
Causality:Yes
Causal Description:Functional analysis showed that MIR99AHG is associated with the LUAD malignant phenotype in vitro and in vivo.
Clinical-realted Application:MIR99AHG levels were associated with poorer patient overall survival.